NX Plus 500

Generic

Indications

Naproxen and Esomeprazole are used to treat the signs and symptoms of osteoarthritis.

• Rheumatoid arthritis is a type of arthritis that affects the joints.
• Ankylosing spondylitis (AS) is a type of arthritis that affects the spine.
• In individuals at risk of NSAID-associated stomach ulcers, to reduce the chance of developing gastric ulcers.

Pharmacology

This is made up of an Esomeprazole Magnesium coating that releases quickly and an enteric-coated Naproxen core. As a result, Esomeprazole is released into the stomach first, followed by Naproxen dissolution in the small intestine.

Naproxen is a nonsteroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic effects. The activity of Naproxen is to stop the production of prostaglandins. Esomeprazole is a proton pump inhibitor that inhibits gastric acid secretion by inhibiting the H+/k+ -ATPase in the gastric parietal cell. By working selectively on the proton pump, Esomeprazole reduces gastric acidity by blocking the final stage in acid generation.

Dosage 

Administration

Interaction

When it comes to medication,

• Concurrent use of NSAIDs and ACE inhibitors, diuretics, and beta-blockers may diminish their antihypertensive effects.
• When this tablet is taken with warfarin, the chance of a bleeding problem is raised.
• Esomeprazole decreases gastric acid secretion and may interfere with the absorption of medicines whose bioavailability is influenced by gastric pH. (eg. Ketoconazole, iron salts and digoxin).

With food and others: Giving Naproxen and Esomeprazole combined with a high-fat meal has little effect on naproxen absorption, but it considerably prolongs tmax by 10 hours and lowers peak plasma concentration (Cmax) by around 12% in healthy volunteers.

Contraindications

• Hypersensitivity to any of the tablet's ingredients or substituted benzimidazoles.
• After taking aspirin or other NSAIDs, you may experience asthmay urticaria or other allergic responses.
• In the case of coronary artery bypass graft (CABG) surgery, use during the peri-operative period.

Side Effects

This medication is generally well tolerated. Erosive gastritis, dyspepsia, gastritis, diarrhea, gastric ulcer, upper abdominal discomfort, nausea, and other unpleasant responses were the most common in clinical trials (>5%).

Pregnancy & Lactation

Category C pregnancy. It should be avoided in late pregnancy since it may cause premature closure of the ductus arteriosus. Because of the Naproxen component, this tablet should not be taken by nursing mothers.

Precautions & Warnings

Patients having a history of cardiovascular disease or risk factors may be at higher risk. In patients with fluid retention or heart failure, this tablet should be used with caution.

Therapeutic Class

Storage Conditions

Protect from light and moisture by storing at a temperature below 30°C. Keep out of children's reach.

Pharmaceutical Name

One Pharma Ltd.