Paloxi 0.5

Generic

 

Indications

Palonosetron indicated in-

• Acute and delayed nausea and vomiting
• Uncontrolled nausea and vomiting
• Chemotherapy-induced nausea and vomiting (CINV): Acute CINV resulting in on the day of treatment with certain types of chemotherapy
• Delayed CINV resulting in on days later with certain types of chemotherapy
• Radiotherapy-induced nausea and vomiting (RINV)
• Post-operative & Post-discharge nausea and vomiting (PONV & PDNV).

 

Pharmacology

Palonosetron is a 5-HT3 antagonist with a high affinity for this receptor and little or no affinity for other receptors. Chemotherapeutic agents are thought to cause nausea and vomiting by releasing serotonin from enterochromaffin cells in the small intestine, which then activates 5-HT3 receptors on nerve terminals.

 

Administration & Dosage

Typical dosage: Adults should take 0.5 mg of the tablet once a day. Adult IV dosage: A single 0.075 mg IV dose should be given over 10 seconds.

Nausea and vomiting caused by chemotherapy: Adult tablet dosage: 0.5 mg, given 1 hour before the start of chemotherapy. Adult IV dosage: A single 0.25 mg IV dose should be given every 30 seconds for about 30 minutes.

 

Interaction

Palonosetron injection has been safely administered with corticosteroids, analgesics, antiemetics/antinauseants, antispasmodics, and anticholinergic agents in controlled clinical trials. In murine tumor models, palonosetron had no effect on the antitumor activity of cisplatin, cyclophosphamide, cytarabine, doxorubicin, or mitomycin C.

 

Contraindications

Palonosetron is not recommended for patients who have a history of hypersensitivity to the drug or any of its ingredients.

 

Side Effect

Headaches and constipation are the most common side effects.

 

Pregnancy & Lactation

The most common side effects are headaches and constipation.

 

Precautions & Warnings

When hypercalcemia occurs, the drug must be stopped immediately. Increased fluid intake should also be recommended to patients who have a history of kidney stone formation.

 

Therapeutic Class

Anti-emetic medications

 

Storage Conditions

Store at or below 30°C, away from light and moisture. Keep out of reach of children.

 

Pharmaceutical Name