Pantonix 20

Indications of Pantonix 20

Pantonix 20 mg is indicated where suppression of acid secretion has therapeutic benefit; i.e.

• Peptic ulcer diseases
• Gastroesophageal reflux diseases
• Ulcer induced by non-steroidal anti-inflammatory drugs (NSAIDs)
• Eradication of Helicobacter pylori (in combination with antibiotics)
• Zollinger-Ellison Syndrome.

 

Pharmaceutical Name of Pantonix 20

Incepta Pharmaceuticals Ltd.

 

Pharmacology

Pantoprazole is a proton pump inhibitor that covalently binds to the H+/K+ATPase enzyme system at the surface of the gastric parietal cell, suppressing the final step in a gastric acid generation. This impact inhibits both basal and induced stomach acid secretion, regardless of whether the stimulus is present for more than 24 hours.

 

Dosage & Administration of Pantonix 20

Oral:

• Benign gastric ulcer: 40 mg daily in the morning for 4 weeks, continued for further 4 weeks, if not fully healed.
• Gastro-esophageal reflux disease: 20-40 mg daily in the morning for 4 weeks, continued for further 4 weeks, if not fully healed; maintenance dose is 20 mg daily, which may be increased to 40 mg daily.
• Duodenal ulcer: 40 mg daily in the morning for 2 weeks, continued for further 2 weeks if not fully healed.
• Duodenal ulcer associated with Helicobacter pylori: Pantoprazole is recommended at a dose of 40 mg twice daily in association with antimicrobial agents as detailed below: Amoxycillin 1 g and Clarithromycin 500 mg both twice daily for one week, or Clarithromycin 250 mg and Metronidazole 400 mg both twice daily for one week.
• Prophylaxis of NSAID-associated gastric or duodenal ulcer: 20 mg daily for those require long-term NSAID treatment.
• Zollinger-Ellison Syndrome: Initially 80 mg once daily adjusted according to response (elderly max. 40 mg daily); daily doses above 80 mg given in 2 divided doses.

IV Injection:

• Duodenal ulcer and gastric ulcer: 40 mg once daily for 7-10 days
• Gastroesophageal reflux disease associated with a history of erosive esophagitis: 40 mg once daily for 7-10 days
• Prevention of rebleeding in peptic ulcer: IV 80 mg, followed by 8 mg/hour infusion for 72 hours
• Prophylaxis of acid aspiration: 80 mg IV every 12 h for 24 h, followed by 40mg every 12 hour
• Long-term management of Zollinger-Ellison Syndrome and other pathological hypersecretory conditions: 80 mg IV every 12 hours, may increase to 80 mg every 8 hours if needed, may titrate to higher doses depending on the acid output.

 

Interaction

No significant drug interactions have been observed in clinical studies.

 

Contraindications

Pantonix 20 mg is not recommended for those who have a known hypersensitivity to any of the formulation's ingredients.

 

Side Effect of Pantonix 20

Pantonix 20 mg is well endured in both short-term and long-term treatment. Migraine and loose bowels are the common side impacts and once in a while included side impacts are stomach torment, tooting, hasty, a sleeping disorder, and hyperglycemia.

 

Pregnancy & Lactation

US FDA Pregnancy Category of Pantoprazole is B. There are, be that as it may, no satisfactory and well-controlled ponders in pregnant ladies. Since creature propagationponders are not continuously prescient of human reaction, this sedate ought to be utilized amid pregnancy as it were on the off chance that clearly required. Pantonix 20 mg has been appeared to be excreted in the human brain. So, a choice ought to be made whether to cease nursing or to cease the sedate, taking into consideration the good thing about the sedate to the mother.

 

Precautions & Warnings

Pantonix 20 mg tablets should not be split, chewed, or crushed, according to the manufacturer. Pantoprazole therapy for a long time may cause cyanocobalamin (Vitamin B12) malabsorption or raise the risk of osteoporosis-related illnesses.

 

Therapeutic Class

Proton Pump Inhibitor.

 

Storage Conditions

Keep away from light and moisture in a cool, dry location (below 30° C). Keep out of children's reach.

 

Generic Name of Pantonix 20

Pantoprazole Sodium Sesquihydrate.

 

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