Protonil 20

Generic

 

Indications

Pantoprazole is demonstrated where concealment of corrosive discharge has restorative advantage; i.e Peptic ulcer diseases Gastroesophageal reflux diseases Ulcer actuated by non-steroidal anti-inflammatory drugs (NSAIDs) Eradication of Helicobacter pylori (in combination with antibiotics) Zollinger-Ellison Disorder

 

Pharmacology

Pantoprazole may be a proton pump inhibitor that stifles the ultimate step in gastric corrosive generation by covalently official to the H+/K+ATPase protein framework at the surface of the gastric parietal cell. This impact leads to restraint of both basal and invigorated gastric corrosive discharge, independent of the jolt that holds on longer than 24 hours.

 

Dosage & Administration

Oral:

• Benign gastric ulcer: 40 mg daily in the morning for 4 weeks, continued for further 4 weeks, if not fully healed.
• Gastro-esophageal reflux disease: 20-40 mg daily in the morning for 4 weeks, continued for further 4 weeks, if not fully healed; maintenance dose is 20 mg daily, which may be increased to 40 mg daily.
• Duodenal ulcer: 40 mg daily in the morning for 2 weeks, continued for further 2 weeks if not fully healed.
• Duodenal ulcer associated with Helicobacter pylori: Pantoprazole is recommended at a dose of 40 mg twice daily in association with antimicrobial agents as detailed below: Amoxycillin 1 g and Clarithromycin 500 mg both twice daily for one week, or Clarithromycin 250 mg and Metronidazole 400 mg both twice daily for one week.
• Prophylaxis of NSAID-associated gastric or duodenal ulcer: 20 mg daily for those require long-term NSAID treatment.
• Zollinger-Ellison Syndrome: Initially 80 mg once daily adjusted according to response (elderly max. 40 mg daily); daily doses above 80 mg given in 2 divided doses.IV Injection:
  
  • Duodenal ulcer and gastric ulcer: 40 mg once daily for 7-10 days
  • Gastroesophageal reflux disease associated with a history of erosive esophagitis: 40 mg once daily for 7-10 days
  • Prevention of rebleeding in peptic ulcer: IV 80 mg, followed by 8 mg/hour infusion for 72 hours
  • Prophylaxis of acid aspiration: 80 mg IV every 12 h for 24 h, followed by 40mg every 12 hour
  • Long-term management of Zollinger-Ellison Syndrome and other pathological hypersecretory conditions: 80 mg IV every 12 hours, may increase to 80 mg every 8 hours if needed, may titrate to higher doses depending on acid output.

 

Interaction

No noteworthy sedate intelligent have been watched in clinical ponders.

 

Contraindications

Pantoprazole is contraindicated in patients with known hypersensitivity to any of the components of the formulation.

 

Side Effects

Pantoprazole is well endured in both short-term and long-term treatment. Migraine and loose bowels are the common side impacts and seldom included side impacts are stomach torment, tooting, hasty, a sleeping disorder and hyperglycemia.

 

Pregnancy & Lactation

US FDA Pregnancy Category of Pantoprazole is B. There are, in any case, no satisfactory and well-controlled considers in pregnant lady. Since creature propagation considers are not continuously prescient of human reaction, this sedate ought to be utilized amid pregnancy as it were in case clearly required. Pantoprazole has been appeared to be excreted in human drain. So, a choice ought to be made whether to cease nursing or to cease the medicate, taking into consideration the good thing about the medicate to the mother.

 

Precautions & Warnings

Patients ought to be cautioned that Pantoprazole tablet ought to not be part, chewed or smashed. Long-term treatment of Pantoprazole may lead to malabsorption of cyanocobalamin (Vitamin B12) or may increment the hazard of osteoporosis related clutters..

 

Therapeutic Class

Proton Pump Inhibitor

 

Storage Conditions

Protect from light and moisture by storing below 30°C. Keep the medicine out of children's reach.

 

Pharmaceutical Name