Phylopen 250

Generic

 

Indications

Flucloxacillin is used to treat infections caused by Gram-positive bacteria, including infections caused by staphylococci that produce penicillinase. These are some of the signs:
Infections of the skin and soft tissues: Boils, abscesses, carbuncles, and infected skin conditions are all examples of infected skin conditions (e.g. ulcer, eczema, acne, furunculosis, cellulitis, infected wounds, infected burns, otitis media and externa, impetigo).

 

Pharmacology

Flucloxacillin is effective against Gram-positive bacteria, including those that produce penicillinase. It has little effect on Gram-negative bacteria. Flucloxacillin works by preventing bacteria from forming cell walls. Flucloxacillin is an isoxazolyl penicillin that combines resistance to hydrolysis by penicillinase with other properties.

 

Administration & Dosage

Administration by mouth:
Adults should take 250 mg four times a day. In severe infections, the dosage may be doubled. Up to 8 gm daily in 6-8 hourly divided doses is used in osteomyelitis and endocarditis.
1/2 of adult dose for children (2-10 years).
Children under the age of two should receive 1/4 of the adult dose.

 

Interaction

Concurrent Flucloxacillin use may result in an elevated Flucloxacillin level in the blood for an extended period of time.

 

Contraindications

Flucloxacillin is not recommended for people who are allergic to penicillin.

 

Side Effect

Nausea, vomiting, diarrhoea, dyspepsia, and other minor gastrointestinal disturbances are some of the most common gastrointestinal side effects. Urticaria, purpura, fever, interstitial nephritis, hepatitis, and cholestatic jaundice have all been reported in addition to these rashes.

 

Pregnancy & Lactation

Flucloxacillin is classified as a pregnancy category B by the US Food and Drug Administration. In pregnant women, there are no adequate and well-controlled studies. Because animal reproduction studies do not always predict human response, this medication should only be used during pregnancy if absolutely necessary.

 

Precautions & Warnings

In patients with hepatic dysfunction, flucloxacillin should be used with caution. In the treatment of patients with allergic diathesis, caution is also advised.

 

Therapeutic Class

Penicillins that are resistant to the enzyme penicillinase.

 

Storage Conditions

Keep the temperature below 30°C and away from light and moisture. Keep out of children's reach.

 

Pharmaceutical Name