Trevox 500

Generic

 

Indications

Levofloxacin is shown for the treatment of gentle, direct and serious contaminations caused by vulnerable strains of the assigned micro-organisms within the condition recorded below: Acute maxillary sinusitis due to Streptococcus pneumoniae, Haemophilus influenzae, or Moraxella catarrhalis. Acute bacterial compounding of unremitting bronchitis due to Staphylococcus aureus, Streptococcus pneumoniae, Haemophilus influenzae, or Moraxella catarrhalis.  Community-acquired pneumonia due to Staphylococcus aureus, Streptococcus pneumoniae, Haemophilus influenzae, Klebsiella pneumoniae, Moraxella catarrhalis, Chlamydia pneumoniae, Legionella pneumophila, or Mycoplasma pneumoniae. Uncomplicated & complicated urinary tract contaminations due to Escherichia coli, Klebsiella pneumoniae, or Staphylococcus saprophyticus. Acute pyelonephritis caused by Escherichia coli. Uncomplicated & complicated skin and delicate tissue contaminations counting abscesses, cellulitis, furuncles, impetigo, pyoderma, wound contaminations.

 

Pharmacology

Levofloxacin is a third-generation fluoroquinolone antibiotic that is synthetic and broad-spectrum. Levofloxacin is a chiral fluorinated carboxyquinolone chemically. The enzymes required for DNA replication, transcription repair, and recombination, bacterial topoisomerase IV and DNA gyrase, are inhibited by levofloxacin. It has activity against a wide range of gm-ve in vitro.       

                                                                                                          

Dosage & Administration

Adults:

• Acute sinusitis: 500 mg once daily for 10-14 days, or 750 mg once daily for 5 days
• Exacerbation of chronic bronchitis: 500 mg once daily for 7 days, or 750 mg once daily for 3 days (Uncomplicated), 750 mg once daily for 5 days (Complicated)
• Community-acquired pneumonia: 500 mg once daily for 7-14 days, or 750 mg once daily for 5 days
• Uncomplicated urinary-tract infections: 250 mg once daily for 3 days
• Complicated urinary-tract infections and acute pyelonephritis: 250 mg once daily for 7-10 days
• Uncomplicated skin and soft-tissue infections: 500 mg once daily for 7-10 days.
• Complicated skin and soft-tissue infections: 750 mg once daily for 7-14 days.
• Enteric fever: 500 mg once daily for 7-14 days.
• Diarrhea, cholera, shigellosis & enteritis: Mild to moderate case: 500 mg (single dose). Moderate to sever case: 500 mg once daily for 3 days

Children:

• Children 6 months to <5 years: 10 mg/kg every 12 hours.
• Children >5 years: 10 mg/kg every 24 hours

 

Interaction

Through the same intravenous line, no quinolone should be given with any solution containing multivalent cations, such as magnesium. Levofloxacin absorption is hampered by antacids, iron, and adsorbents. The use of nonsteroidal anti-inflammatory drugs (NSAIDs) may increase the risk of CNS stimulation. Warfarin can make you bleed more easily.

 

Contraindications

Patients with a history of hypersensitivity to levofloxacin, quinolone antimicrobial agents, or any other component of this product should not take it.

 

Side Effects

Levofloxacin is well tolerated by most people. However, there are usually a few side effects. Retinal detachment is a possibility. Nausea, vomiting, diarrhea, abdominal pain, flatulence, and phototoxicity are some of the other side effects (0.1 percent ). Tremors, depression, anxiety, and confusion are some of the rare side effects that may occur.

 

Pregnancy & Lactation

Because the effects on the unborn child or nursing infant are unknown, levofloxacin is not recommended for use during pregnancy or nursing.

 

Precautions & Warnings

During the administration of Levofloxacin, the following precautions should be taken:
Levofloxacin Depending on the dosage, injection should only be given as a slow intravenous infusion over a period of 60 or 90 minutes.
A sufficient amount of water should be consumed while taking Levofloxacin to avoid a concentrated form of urine.
During the administration of Levofloxacin, dosage adjustments should be made.

 

Therapeutic Class

Preparations containing four quinolones

 

Storage Conditions

Protect from light and moisture by storing in a cool, dry place below 30°C. Keep out of children's reach.

 

Pharmaceutical Name

Square Pharmaceuticals Ltd.