Bislol Plus 5 Tablet
by Opsonin Pharma Limited
৳11.50
Popular Pharmaceuticals Ltd.
Betacor HZ 5/6.25 tablet from Popular Pharmaceuticals & Bisoprolol Fumarate 5mg + Hydrochlorothiazide 6.25mg. The combination of Bisoprolol and Hydrochlorothiazide is used to treat hypertension.
Bisoprolol plus Hydrochlorothiazide is indicated in the treatment of Hypertension.
Bisoprolol fumarate and hydrochlorothiazide have been used individually or in combination to treat high blood pressure. The coercive effect of this drug is additive. Hydrochlorothiazide 6.25mg can significantly enhance the anti-pressurizing effect of bisoprolol fumarate. The incidence of hypokalemia by the combination of bisoprolol fumarate and hydrochlorothiazide 6.25mg is much lower than that of hydrochlorothiazide 25mg. Bisoprolol fumarate is a β1-selective (cardioselective) adrenergic receptor blocker and does not exhibit significant membrane stabilization or endogenous sympathomimetic action over the therapeutic dose range. Hydrochlorothiazide is a benzoasiazine diuretic. Chiajido affects the tubular mechanism of electrolyte reabsorption, and increases the excretion of sodium and chloride in approximately equal amounts.
Bisoprolol is an effective treatment of hypertension in once-daily doses of 2.5 to 40 mg, while Hydrochlorothiazide is effective in doses of 12.5 to 50 mg. In clinical trials of Bisoprolol/Hydrochlorothiazide combination therapy using Bisoprolol doses of 2.5 to 20 mg and Hydrochlorothiazide doses of 6.25 to 25 mg, the antihypertensive effects increased with increasing doses of either component.
Initial Therapy: Antihypertensive therapy may be initiated with the lowest dose of this conbination, one 2.5/6.25 mg tablet once daily. Subsequent titration (14 day intervals) may be carried out with this tablets up to the maximum recommended dose 20/12.5 mg once daily, as appropriate.
Replacement Therapy: The combination may be substituted for the titrated individual components.
Therapy Guided by Clinical Effect: A patient whose blood pressure is not adequately controlled with 2.5-20 mg Bisoprolol daily may instead be given this conbination. Patients whose blood pressures are adequately controlled with 50 mg of hydrochlorothiazide daily, but who experience significant potassium loss with this regimen, may achieve similar blood pressure control without electrolyte disturbance if they are switched to this conbination.
This combined medicine may increase the effect of other antihypertensive medicines used simultaneously. This drug combination should not be combined with other beta-blocking agents. Patients receiving catecholamine-reducing drugs, such as reserpine or guanethidine, should be closely monitored, as the beta-adrenergic blocking effects of bisoprolol fumarate may cause an excessive reduction in sympathetic activity. In patients receiving concomitant treatment with clonidine, if treatment must be discontinued, the combination should be discontinued for several days before stopping clonidine. This drug combination should be used with caution when taking cardiac muscle inhibitors or inhibitors of AV conduction, such as certain calcium antagonists (especially phenylalkylamine [verapamil] and benzothiazepine [diltiazem]) classes, or antiarrhythmic drugs, such as disopyramide, are used simultaneously. Digitalis glycosides and beta blockers slow atrioventricular conduction and decrease heart rate. Concomitant use may increase the risk of bradycardia.
Patients with cardiogenic shock, obvious heart failure, second-degree or third-degree atrioventricular block, obvious sinus bradycardia, anuria, and those who are allergic to any component of this product or other sulfonamide-derived drugs are contraindicated.
Generally, well tolerated. Most side effects are mild and short-lived. Possible side effects: fatigue, dizziness, headache, bradycardia, arrhythmia, peripheral ischemia, chest pain, palpitations, rhythm disturbance, cold limbs, claudication, orthostatic hypotension, diarrhea, constipation, nausea, dyspepsia, rhinitis , Pharyngitis, etc.
Use during pregnancy: Pregnancy category C. There are no suitable and well-controlled studies of pregnant women. Bisoprolol Fumarate and Hydrochlorothiazide should only be used during pregnancy if the potential benefits justify the risk to the foetation.
For use in lactating women: Not in studies of lactating mothers with Bisoprolol Fumarate alone or in combination with Hydrochlorothiazide. Tiaazid is excreted in human breast milk. Small amounts of bisoprolol fumarate were detected in the breast milk of lactating mice. Because lactating infants can experience serious side effects, the importance of the drug to the mother should be taken into account when deciding whether to stop breastfeeding or discontinue the drug.
Hyperuricemia or acute gout may be precipitated in some patients receiving thiazide diuretics. Warning signs or symptoms of fluid and electrolyte imbalance include dry mouth, thirst, weakness, lethargy, drowsiness, restlessness, muscle aches or cramps, muscle fatigue, hypotension, oliguria, tachycardia and gastrointestinal disturbances such as nausea and vomiting. Hypokalemia may develop. If discontinuation of this combination therapy is planned, it should be done gradually over a period of approximately 2 weeks. The patient should be carefully observed.
Combined antihypertensive preparations
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.
Bisoprolol Fumarate + Hydrochlorothiazide
by Square Pharmaceuticals Limited
৳10.03