Bisoren Plus 5

Indications of Bisoren Plus 5 Tablet

The combination of Bisoprolol and Hydrochlorothiazide is used to treat hypertension.

Pharmacology of Bisoren Plus 5 Tablet

Individually and in combination, Bisoprolol Fumarate and Hydrochlorothiazide have been used to treat hypertension. The antihypertensive effects of these drugs are cumulative; Hydrochlorothiazide 6.25 mg greatly boosts Bisoprolol Fumarate's antihypertensive action. Hypokalemia was more common with Bisoprolol Fumarate and Hydrochlorothiazide 6.25 mg when compared to Hydrochlorothiazide 25 mg, the combination is much less effective. In its therapeutic dose range, Bisoprolol Fumarate is a 1-selective (cardioselective) adrenoceptor blocking drug with no appreciable membrane stabilizing or intrinsic sympathomimetic effects. A benzothiadiazine diuretic is hydrochlorothiazide. Thiazides have an effect on the electrolyte reabsorption pathways in the renal tubules and increase sodium and chloride excretion in about equal proportions.

Dosage & Administration of Bisoren Plus 5 Tablet

Bisoprolol is an effective treatment of hypertension in once-daily doses of 2.5 to 40 mg, while Hydrochlorothiazide is effective in doses of 12.5 to 50 mg. In clinical trials of Bisoprolol/Hydrochlorothiazide combination therapy using Bisoprolol doses of 2.5 to 20 mg and Hydrochlorothiazide doses of 6.25 to 25 mg, the antihypertensive effects increased with increasing doses of either component.

Initial Therapy: Antihypertensive therapy may be initiated with the lowest dose of this conbination, one 2.5/6.25 mg tablet once daily. Subsequent titration (14 day intervals) may be carried out with this tablets up to the maximum recommended dose 20/12.5 mg once daily, as appropriate.

Replacement Therapy: The combination may be substituted for the titrated individual components.

Therapy Guided by Clinical Effect: A patient whose blood pressure is not adequately controlled with 2.5-20 mg Bisoprolol daily may instead be given this conbination. Patients whose blood pressures are adequately controlled with 50 mg of hydrochlorothiazide daily, but who experience significant potassium loss with this regimen, may achieve similar blood pressure control without electrolyte disturbance if they are switched to this conbination.

Interaction of Bisoren Plus 5 Tablet

This combination drug may enhance the effects of other antihypertensive drugs used at the same time. Other beta-blocking medications should not be taken with this combo therapy. Patients using catecholamine-depleting medicines like reserpine or guanethidine should be constantly watched because Bisoprolol Fumarate's additional beta-adrenergic blocking action may cause an excessive reduction in sympathetic activity. In patients receiving concurrent therapy with clonidine, If therapy is to be stopped, it is recommended that this combo medicine be stopped for a few days before clonidine is stopped. When myocardial depressants or AV conduction inhibitors, such as calcium antagonists (especially of the phenylalkylamine and benzothiazepine [diltiazem] classes) or antiarrhythmic medicines, are administered, this combination medication should be used with caution.

Contraindications

Cardiogenic shock, overt heart failure, second or third degree AV block, significant sinus bradycardia, anuria, and hypersensitivity to any component of this product or other sulfonamide-derived medications are all contraindications.

Side Effects of Bisoren Plus 5 Tablet

In general, it is well tolerated. The majority of side effects have been minor and short-lived. Fatigue, dizziness, headache, bradycardia, arrhythmia, peripheral ischemia, chest discomfort, palpitations, rhythm abnormalities, cold extremities, claudication, orthostatic hypotension, diarrhoea, constipation, nausea, dyspepsia, rhinitis, pharyngitis, etc. are some of the side symptoms that may occur.

Pregnancy & Lactation

Use in Pregnancy: Pregnancy Category C. In pregnant women, there are no sufficient and well-controlled trials. Only if the possible benefit outweighs the risk to the fetus should Bisoprolol Fumarate and Hydrochlorothiazide be used during pregnancy.

Use in Nursing Mothers: In nursing moms, Bisoprolol Fumarate alone or in combination with Hydrochlorothiazide has not been researched. Human breast milk contains thiazides, which are expelled. Bisoprolol Fumarate was found in trace levels in the milk of nursing rats. Because of the risk of major side effects in nursing infants, a choice should be taken about whether to stop nursing or stop taking the medicine.

Precautions & Warnings

Certain people on thiazide diuretics may develop hyperuricemia or severe gout. Dry mouth, thirst, weakness, lethargy, drowsiness, restlessness, muscle pains or cramps, muscular tiredness, hypotension, oliguria, tachycardia, and gastrointestinal disturbances such as nausea and vomiting are all warning indications or symptoms of fluid and electrolyte imbalance. Hypokalemia can occur. If you want to stop taking this combo therapy, you should do so gradually over a two-week period. Patients should be carefully observed.

Therapeutic Class

Antihypertensive medications in combination.

Storage Conditions

Keep the temperature below 30°C and away from light and moisture. Keep out of children's reach.

Pharmaceutical Name of Bisoren Plus 5 Tablet

RENATA LIMITED

Generic of Bisoren Plus 5 Tablet

Bisoprolol Fumarate + Hydrochlorothiazide