Bislol Plus 2.5

Indications of Bislol Plus 2.5 Tablet

The combination of Bisoprolol and Hydrochlorothiazide is used to treat hypertension.

Pharmacology of Bislol Plus 2.5 Tablet

Individually and in combination, Bisoprolol Fumarate and Hydrochlorothiazide have been used to treat hypertension. The antihypertensive effects of these drugs are cumulative; Hydrochlorothiazide 6.25 mg greatly boosts Bisoprolol Fumarate's antihypertensive action. The combination of Bisoprolol Fumarate and Hydrochlorothiazide 6.25 mg causes much less hypokalemia than Hydrochlorothiazide 25 mg. In its therapeutic dose range, Bisoprolol Fumarate is a 1-selective (cardioselective) adrenoceptor blocking drug with no appreciable membrane stabilizing or intrinsic sympathomimetic effects. A benzothiadiazine diuretic is hydrochlorothiazide. Thiazides impact renal tubular electrolyte reabsorption pathways and increase sodium and chloride excretion in roughly equal proportions.

Dosage & Administration of Bislol Plus 2.5 Tablet

Bisoprolol is an effective treatment of hypertension in once-daily doses of 2.5 to 40 mg, while Hydrochlorothiazide is effective in doses of 12.5 to 50 mg. In clinical trials of Bisoprolol/Hydrochlorothiazide combination therapy using Bisoprolol doses of 2.5 to 20 mg and Hydrochlorothiazide doses of 6.25 to 25 mg, the antihypertensive effects increased with increasing doses of either component.

Initial Therapy: Antihypertensive therapy may be initiated with the lowest dose of this conbination, one 2.5/6.25 mg tablet once daily. Subsequent titration (14 day intervals) may be carried out with this tablets up to the maximum recommended dose 20/12.5 mg once daily, as appropriate.

Interactions of Bislol Plus 2.5 Tablet

This combination medicine may enhance the effects of other antihypertensive medications used at the same time. Other beta-blocking medications should not be taken with this combo therapy. Patients using catecholamine-depleting medicines like reserpine or guanethidine should be properly monitored since Bisoprolol Fumarate's extra beta-adrenergic blocking activity may produce an abnormality in sympathetic activity. If clonidine therapy is to be stopped, it is recommended that this combo medicine be stopped for many days before the clonidine is stopped. When cardiac depressants or inhibitors of AV conduction, such as calcium antagonists (especially of the phenylalkylamine [verapamil] and benzothiazepine [diltiazem] classes) or antiarrhythmic medicines, such as disopyramide, are administered concurrently, this combination medication should be used with caution. Beta-blockers and digitalis glycosides both delay atrioventricular conduction and lower heart rate. Concurrent use can put you at risk for bradycardia.

Contraindications

Cardiogenic shock, overt heart failure, second or third degree AV block, significant sinus bradycardia, anuria, and hypersensitivity to any component of this product or other sulfonamide-derived medications are all contraindications.

Side-Effects of Bislol Plus 2.5 Tablet

In general, it is well tolerated. The majority of side effects have been minor and short-lived. Fatigue, dizziness, headache, bradycardia, arrhythmia, peripheral ischemia, chest discomfort, palpitations, rhythm abnormalities, cold extremities, claudication, orthostatic hypotension, diarrhoea, constipation, nausea, dyspepsia, rhinitis, pharyngitis, etc. are some of the side symptoms that may occur.

Pregnancy

Pregnancy Category C (Use During Pregnancy). In pregnant women, there are no sufficient and well-controlled trials. Only if the possible benefit outweighs the risk to the fetus should Bisoprolol Fumarate and Hydrochlorothiazide be used during pregnancy.

Bisoprolol Fumarate has not been investigated in nursing women, either alone or in conjunction with Hydrochlorothiazide. Human breast milk contains thiazides, which are expelled. Bisoprolol Fumarate was found in trace levels in the milk of nursing rats. Because of the risk of major adverse reactions in nursing infants, a choice should be made on whether to stop breastfeeding or stop taking the drug, with the importance of the drug to the mother taken into account.

Precautions

Certain people on thiazide diuretics may develop hyperuricemia or severe gout. Dry mouth, thirst, weakness, lethargy, drowsiness, restlessness, muscle pains or cramps, muscular tiredness, hypotension, oliguria, tachycardia, and gastrointestinal disturbances such as nausea and vomiting are all warning indications or symptoms of fluid and electrolyte imbalance. Hypokalemia can occur. If you want to stop taking this combo therapy, you should do so gradually over a two-week period. Patients should be closely monitored.

Therapeutic Class

Antihypertensive medications in combination

Storage Conditions

Keep the temperature below 30°C and away from light and moisture. Keep out of children's reach.

Pharmaceutical Name of Bislol Plus 2.5 Tablet

Opsonin Pharma Ltd

Generic of Bislol Plus 2.5 Tablet

Bisoprolol Fumarate + Hydrochlorothiazide