Tenobis Plus 5

Indications of Tenobis Plus 5 Tablet

The combination of Bisoprolol and Hydrochlorothiazide is used to treat hypertension.

Pharmacology of Tenobis Plus 5 Tablet

Individually and in combination, Bisoprolol Fumarate and Hydrochlorothiazide have been used to treat hypertension. The antihypertensive effects of these drugs are cumulative; Hydrochlorothiazide 6.25 mg considerably boosts Bisoprolol Fumarate's antihypertensive impact. The combination of Bisoprolol Fumarate and Hydrochlorothiazide 6.25 mg causes considerably less hypokalemia than Hydrochlorothiazide 25 mg. Bisoprolol In its therapeutic dosage range, fumarate is a 1-selective (cardioselective) adrenoceptor blocking drug with no substantial membrane stabilizing or intrinsic sympathomimetic effects. A benzothiadiazine diuretic is hydrochlorothiazide. Thiazides alter renal tubular electrolyte reabsorption processes and increase sodium and chloride excretion in about equal quantities.

Dosage & Administration of Tenobis Plus 5 Tablet

Bisoprolol is an effective treatment of hypertension in once-daily doses of 2.5 to 40 mg, while Hydrochlorothiazide is effective in doses of 12.5 to 50 mg. In clinical trials of Bisoprolol/Hydrochlorothiazide combination therapy using Bisoprolol doses of 2.5 to 20 mg and Hydrochlorothiazide doses of 6.25 to 25 mg, the antihypertensive effects increased with increasing doses of either component.

Initial Therapy: Antihypertensive therapy may be initiated with the lowest dose of this conbination, one 2.5/6.25 mg tablet once daily. Subsequent titration (14 day intervals) may be carried out with this tablets up to the maximum recommended dose 20/12.5 mg once daily, as appropriate.

Replacement Therapy: The combination may be substituted for the titrated individual components.

Therapy Guided by Clinical Effect: A patient whose blood pressure is not adequately controlled with 2.5-20 mg Bisoprolol daily may instead be given this conbination. Patients whose blood pressures are adequately controlled with 50 mg of hydrochlorothiazide daily, but who experience significant potassium loss with this regimen, may achieve similar blood pressure control without electrolyte disturbance if they are switched to this conbination.

Interaction of Tenobis Plus 5 Tablet

This combination drug may potentiate the action of other antihypertensive agents used concomitantly. This combination drug should not be combined with other beta-blocking agents. Patients receiving catecholamine-depleting drugs, such as reserpine or guanethidine, should be closely monitored because the added beta-adrenergic blocking action of Bisoprolol Fumarate may produce excessive reduction of sympathetic activity. In patients receiving concurrent therapy with clonidine, if therapy is to be discontinued, it is suggested that this combination drug be discontinued for several days before the withdrawal of clonidine. This combination drug should be used with caution when myocardial depressants or inhibitors of AV conduction, such as certain calcium antagonists (particularly of the phenylalkylamine [verapamil] and benzothiazepine [diltiazem] classes) or antiarrhythmic agents, such as disopyramide, are used concurrently. Both digitalis glycosides and beta-blockers slow atrioventricular conduction and decrease heart rate. Concomitant use can increase the risk of bradycardia.

Contraindications

Cardiogenic shock, overt heart failure, second or third degree AV block, significant sinus bradycardia, anuria, and allergy to any component of this product or other sulfonamide-derived medicines are all contraindications.

Side Effect of Tenobis Plus 5 Tablet

In general, it is well tolerated. The majority of adverse effects have been minor and short-lived. Fatigue, dizziness, headache, bradycardia, arrhythmia, peripheral ischemia, chest discomfort, palpitations, rhythm abnormalities, cold extremities, claudication, orthostatic hypotension, diarrhoea, constipation, nausea, dyspepsia, rhinitis, pharyngitis, etc. are some of the side symptoms that may occur.

Pregnancy & Lactation

Pregnancy Category C (Use During Pregnancy). In pregnant women, there are no appropriate and well-controlled trials. Only if the possible benefit outweighs the danger to the fetus should Bisoprolol Fumarate and Hydrochlorothiazide be taken during pregnancy.

Bisoprolol Fumarate has not been tested in nursing women, either alone or in conjunction with Hydrochlorothiazide. Human breast milk contains thiazides, which are expelled. Bisoprolol Fumarate was found in trace quantities in the milk of nursing rats. Because of the risk of significant adverse effects in nursing infants, a choice should be made on whether to stop breastfeeding or stop taking the medicine, with the value of the drug to the mother taken into account.

Precautions & Warnings

Certain people on thiazide diuretics may develop hyperuricemia or severe gout. Dry mouth, thirst, weakness, lethargy, sleepiness, restlessness, muscle aches or cramps, muscular exhaustion, hypotension, oliguria, tachycardia, and gastrointestinal disturbances such as nausea and vomiting are all warning indications or symptoms of fluid and electrolyte imbalance. Hypokalemia can occur. If you want to stop taking this combo therapy, you should do so gradually over a two-week period. Patients should be closely monitored.

Therapeutic Class

Combined antihypertensive preparations

Storage Conditions

Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.

Pharmaceutical Name of Tenobis Plus 5 Tablet

Drug International Ltd

Generic of Tenobis Plus 5 Tablet

Bisoprolol Fumarate + Hydrochlorothiazide