Doxicap 100

Indications of Doxicap 100

• Infections produced by susceptible microorganisms are treated with doxycycline hydrochloride.
• Pneumonia, influenza, sinusitis, bronchitis, tonsillitis, and tracheitis are examples of respiratory tract illnesses.
• Cholera, traveler's diarrhea, shigella dysentery, and acute intestinal amebiasis are examples of gastrointestinal tract illnesses.
• Lymphogranuloma venereum, psittacosis, and trachoma are all chlamydial diseases.
• Nongonococcal urethritis, acute pelvic inflammatory disease, uncomplicated urethral, endocervical, or rectal infections, gonorrhea, syphilis, pyelonephritis, and cystitis are all sexually transmitted diseases.
• Impetigo, furunculosis, inclusion conjunctivitis, brucellosis, tularemia, cellulitis, acne, and Q-fever are some of the other infections that can be contracted.

 

Pharmacology

Doxicap is a semisynthetic tetracycline antibiotic with broad-spectrum activity. It is primarily a bacteriostatic antibiotic. It has a similar spectrum of activity to other tetracyclines but in particular, is more active against Staphylococcus aureus and Nocardia. The drug is often active against penicillin-resistant strains of Staphylococcus aureus and against strains of those organisms that are resistant to other Tetracyclines. Certain Gram-negative strains of E. coli, Proteus mirabilis, and Klebsiella, which are often resistant to Tetracycline, may be sensitive to Doxycycline. In addition, 70-90% of the various anaerobes are sensitive to Doxycycline and Bacteroides fragilis is more likely to be sensitive to Doxycycline than to other tetracyclines.

Doxycycline is active against most strains of Haemophilus influenza and is particularly useful for infections with H. ducreyi, Actinomyces, Brucella, and Vibrio cholera. It is also active against Nocardia, Chlamydia, Mycoplasma, and a wide range of Rickettsiae. Doxycycline is active against spirochetes such as Borellia recurrentis, Treponema pallidum, and Treponema pertenue. It is also active against Plasmodium falciparum.

 

Dosage & Administration

Usual dose: 200 mg on the first day, then 100 mg daily for 7-10 days.
Severe infections (including refractory urinary tract infections): 200 mg daily for 10 days.
Acne: 100 mg daily.
Uncomplicated genital chlamydia, non-gonococcal urethritis: 100 mg twice daily for 7-21 days (14-21 days in pelvic inflammatory disease).

 

Interaction of Doxicap 100

Absorption of tetracyclines is impaired by antacid containing aluminum, calcium, or magnesium, and iron-containing preparation. The absorption of tetracyclines is also impaired by bismuth salicylate. Barbiturates, carbamazepine, and phenytoin decrease the half-life of doxycycline. Concurrent use of tetracyclines may render oral contraceptives less effective. Patients who are on anticoagulant therapy may require downward adjustment of their anticoagulant dosages. It is advisable to avoid giving tetracyclines in conjunction with penicillin.

 

Contraindications

Doxycycline is contraindicated to the patients who have shown hypersensitivity to any of the tetracyclines. Doxycycline is contraindicated to children under 8 years of age. It is also contraindicated to pregnant women and to lactating mothers.

 

Side Effects of Doxicap 100

Nausea, vomiting, diarrhea, skin rashes, hemolytic anemia, eosinophilia may be reported.

 

Pregnancy & Lactation

Doxycycline should be avoided in pregnant women, because of the risk of both staining and the effect on bone growth in the fetus. Doxycyclines enter breast milk, and mothers taking these drugs should not breastfeed their children.

 

Precautions & Warnings

The use of drugs of the tetracycline class during tooth development (last half of pregnancy, infancy, and childhood to the age of 8 years) may cause permanent discoloration of teeth. Tetracyclines drugs, therefore should not be used in this age group.

 

Therapeutic Class

Tetracycline is a class of antibiotics.

 

Storage Conditions

Keep all medicines out of reach of children. Store in a cool and dry place, protected from light. 

 

Pharmaceutical Name of Doxicap 100

RENATA LIMITED

 

Generic of Doxicap 100

Doxycycline Hydrochloride

 

Related Products

• Doxin 100
• Doxacil