Doxin 100

Indications of Doxin 100

Infections produced by susceptible microorganisms are treated with doxycycline hydrochloride.Pneumonia, influenza, sinusitis, bronchitis, tonsillitis, and tracheitis are examples of respiratory tract illnesses.Cholera, traveler's diarrhea, shigella dysentery, and acute intestinal amebiasis are examples of gastrointestinal tract illnesses.Lympho-granuloma venereum, psittacosis, and trachoma are all chlamydial diseases.Nongonococcal urethritis, acute pelvic inflammatory disease, uncomplicated urethral and endocervical or rectal infections, gonorrhoea, syphilis, pyelonephritis, cystitis are all sexually transmitted disorders. Impetigo, furunculosis, inclusion conjunctivitis, brucellosis, tularemia, cellulitis, acne, and Q-fever are among the other illnesses.

 

Pharmaceutical Name

Opsonin Pharma Limited

 

Pharmacology

Doxycycline Hydrochloride is a broad-spectrum semisynthetic tetracycline antibiotic. It's a bacteriostatic antibiotic first and foremost. Its spectrum of activity is comparable to that of other tetracyclines, although it is particularly effective against Staphylococcus aureus and Nocardia. The antibiotic is often effective against penicillin-resistant strains of Staphylococcus aureus as well as strains resistant to other Tetracyclines. Doxycycline may be sensitive to Gram-negative E. coli, Proteus mirabilis, and Klebsiella bacteria that are resistant to Tetracycline. Furthermore, Doxycycline is sensitive to 70-90 percent of anaerobes, and Bacteroides fragilis is more likely to be sensitive to Doxycycline than to other tetracyclines.

Doxycycline is effective against most types of Haemophilus influenzae, as well as H. ducreyi, Actinomyces, Brucella, and Vibrio cholerae infections. It also fights Nocardia, Chlamydia, Mycoplasma, and a variety of Rickettsiae. Borellia recurrentis, Treponema pallidum, and Treponema pertenue are all spirochetes that can be treated with doxycycline. It works against Plasmodium falciparum as well.

 

Dosage and Administration

Usual dose: 200 mg on first day, then 100 mg daily for 7-10 days.
Severe infections (including refractory urinary tract infections): 200 mg daily for 10 days.
Acne: 100 mg daily.
Uncomplicated genital chlamydia, non-gonococcal urethritis: 100 mg twice daily for 7-21 days (14-21 days in pelvic inflammatory disease).

 

Interaction of Doxin 100

Antacids containing aluminum, calcium, or magnesium, as well as iron-containing preparations, reduce tetracycline absorption. Bismuth salicylate also inhibits tetracycline absorption. Doxycycline's half-life is shortened by barbiturates, carbamazepine, and phenytoin. Oral contraception may be less effective if tetracyclines are taken at the same time. Patients on anticoagulant medication may need to adjust their anticoagulant dosages downward. Tetracyclines should never be used in conjunction with penicillin.

 

Contraindications

Patients who have exhibited hypersensitivity to any of the tetracyclines should avoid taking Doxycycline. Doxycycline is not recommended for children under the age of eight. It is also not recommended for pregnant women or nursing mothers.

 

Side Effects of Doxin 100

It is possible to experience nausea, vomiting, diarrhoea, skin rashes, hemolytic anemia, and eosinophilia.

 

Pregnancy & Lactation

Doxycycline should be avoided by pregnant women due to the potential of staining and a negative impact on the foetus' bone formation. Doxycyclines pass into breast milk, thus moms who are taking them should not nurse their babies.

 

Precautions & Warnings

The use of tetracycline-class medications during tooth development (final half of pregnancy, infancy, and childhood until the age of eight years) can result in permanent tooth discolouration. As a result, tetracycline medications should not be utilized in this age range.

 

Therapeutic Class

Tetracycline group of drugs

 

Storage Conditions

All drugs should be kept out of the reach of youngsters. Store in a cold, dry, and light-protected location.

 

Generic of Doxin 100

Doxycycline Hydrochloride