Ebasten FT

Indications of Ebasten FT

• Seasonal and Perennial Allergic Rhinitis are treated with Ebastine as a symptomatic therapy.
• Urticaria idiopathica (chronic idiopathic urticaria).

 

Pharmaceutical Name

ACI Limited.

 

Pharmacology

Ebastine is a long-acting and selective antagonist of the H1-histamine receptor. The blockage of peripheral receptors stays stable after repeated treatment. Following oral administration, ebastine is readily absorbed and undergoes significant first-pass metabolism. Carebastine, a pharmacologically active acid metabolite, is almost completely transformed from ebastine.

 

Dosage & Administration

Tablet:

• Adults (more than 12 years of age): 10 mg (one tablet) once daily.
• Children (6-12 years of age): 5 mg (half tablet) once daily.

Syrup:

• Children (2-5 years of age):5 ml once daily (upto 5 ml in severe cases such as Perennial Allergic Rhinitis).
• Children (6-12 years of age): 5 ml once daily (upto 10 ml in severe cases such as Perennial Allergic Rhinitis).

Ebastine may be taken with or without food.

 

Interaction of Ebasten FT

When ebastine is used with either ketoconazole or erythromycin, the plasma level of ebastine rises, resulting in a longer QTc interval. Ebastine had no effect on theophylline, warfarin, cimetidine, diazepam, or alcohol pharmacokinetics. Alcohol plus diazepam's sedative effects may be amplified.

 

Contraindications

Patients who have previously tested positive for Ebastine or any of its components.

 

Side Effects of Ebasten FT

Headache, dry mouth, and sleepiness are the most prevalent adverse effects. Abdominal discomfort, dyspepsia, nausea, and sleeplessness are less typically reported adverse effects.

 

Pregnancy & Lactation

There are limited amount of data from the use of ebastine in pregnant women. Animal studies do not indicate direct or indirect harmful effects with respect to reproductive toxicity. As a precautionary measure, it is preferable to avoid the use of ebastine during pregnancy.

 

Therapeutic Class

Non-sedating antihistamines

 

Storage Conditions

Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.

 

Generic of Ebasten FT

Ebastine