Tebast

Indications of Tebast

Seasonal and Perennial Allergic Rhinitis are treated with Ebastine as a symptomatic treatment.
Urticaria idiopathica (chronic idiopathic urticaria).

 

Pharmaceutical Name of Tebast

Pharmacology

Ebastine is a long-acting and selective antagonist of the H1-histamine receptor. The inhibition of peripheral receptors remains constant after repeated administration. Following oral administration, ebastine is rapidly absorbed and undergoes extensive first-pass metabolism. Carebastine, a pharmacologically active acid metabolite, is almost completely converted from ebastine.

 

Administration & Dosage

Tablet:

• Adults (more than 12 years of age): 10 mg (one tablet) once daily.
• Children (6-12 years of age): 5 mg (half tablet) once daily.

Syrup:

• Children (2-5 years of age): 2.5 ml once daily (upto 5 ml in severe cases such as Perennial Allergic Rhinitis).
• Children (6-12 years of age): 5 ml once daily (upto 10 ml in severe cases such as Perennial Allergic Rhinitis).

Ebastine may be taken with or without food.

 

Interaction of Tebast

When ebastine is taken with either ketoconazole or erythromycin, the plasma level of ebastine rises, resulting in a longer QTc interval. Ebastine has no effect on theophylline, warfarin, cimetidine, diazepam, or alcohol pharmacokinetics. Alcohol and diazepam's sedative effects may be amplified.

 

Contraindications

Patients who have previously tested positive for Ebastine or any of its ingredients.

 

Side Effect of Tebast

Headache, dry mouth, and drowsiness are the most common side effects. Abdominal pain, dyspepsia, nausea, and insomnia are less commonly reported side effects.

 

Pregnancy & Lactation

Only if the potential benefit outweighs the risk to the fetus should the drug be used during pregnancy. This drug is not known to be excreted in human milk. Because of the potential for tumorigenecity shown in some animal studies for Salbutamol, a decision should be made whether to stop nursing or stop taking the drug, taking into account the drug's importance to the patient.

 

Precautions & Warnings

In patients with epilepsy (avoid if poorly controlled, discontinue if convulsions develop), concurrent electroconvulsive therapy (prolonged seizures reported with fluoxetine), history of mania, cardiac disease, diabetes mellitus, angle-closure glaucoma, concomitant use of drugs that increase bleeding risk, and history of bleeding disorders, SSRIs should be used with caution.

 

Therapeutic Class

Antihistamines that don't make you sleepy

 

Storage Conditions

Protect from light and moisture by storing below 30°C. Keep the medicine out of children's reach.