Fluclox 500 Capsule
by ACI Limited
৳14.00
Renata Pharma Ltd
Flucloxacillin Sodium
Flustar® is indicated for the treatment of infections due to Gram-positive organisms, including infections caused by beta-lactamase producing Staphylococci.
Typical indications include: Skin and soft tissue infections: Boils, abscesses, carbuncles, infected skin conditions- for example, ulcer, eczema and acne. Furunculosis, cellulitis, infected wounds, infected bums, protection for skin grafts, otitis media and external impetigo. Respiratory tract infections: Pneumonia, lung abscess, empyema, sinusitis, pharyngitis, tonsillitis, quinsy. Other infections caused by Flustar® sensitive organisms: Osteomyelitis, enteritis, endocarditis, urinary tract infections, meningitis, septicemia.
Flucloxacillin is dynamic against Gram-positive life forms counting penicillinase creating strains. It has small action against Gram-negative bacilli. Flucloxacillin acts by restraining the arrangement of cell divider of microbes. Flucloxacillin is isoxazolyl penicillin which combined the properties of resistance to hydrolysis by penicillinase, gastric corrosive steadiness and action against gram-positive microscopic organisms. Flucloxacillin may be a bactericidal anti-microbial that's especially valuable against penicillinase-producing staphylococci. Flucloxacillin slaughters bacterial cellwall, hence interferometer with peptidoglycan blend. Peptidoglycan could be a heteropolymeric structure that gives the cell divider with its mechanical solidness. The ultimate arrange of peptidoglycan union includes the completion of the cross-linking with the terminal glycine buildup of the pentaglycin bridge connecting to the fourth buildup of the pentapeptide (D-alanine). The transpeptidase protein that performs this step is restrained by Flucloxacillin. As a result the bacterial cellwall is debilitated, the cell swells and after that cracks. Flucloxacillin stands up to the activity of bacterial penicillinase likely since of the steric prevention actuated by the acyl side chain which anticipates the opening of the β- lactam ring.
Should be administered half to one hour before meals.
Usual adult dosage (including elderly patients): 250mg four times daily.
In severe infections: Dosage should be doubled.
In osteomyelitis, endocarditis: Upto 8g daily in divided doses 6 to 8 hourly.
In case of secondary bacterial infection in chicken pox: Flustar® 500mg 6 hourly.
Usual child dosage:
2-10 years: Half of the adult dosage.
Under 2 years: Quarter of the adult dosage.
Children have been given doses of 12.5 to 25mg per kg body weight 4 times daily.
The administration of probenecid with Flucloxacillin results in higher serum peak concentrations and prolong the time that therapeutic concentrations of Flucloxacillin are achieved in serum. Physical incompatibility and/or loss of activity of Flucloxacillin in solution has been reported when given with
gentamycin sulphate, streptomycin sulphate, vitamin mixtures.
Penicillin hypersensitivity, ocular administration
Side effects, as with other penicillins, are uncommon and mainly of a mild and transitory nature, gastrointestinal upsets (e.g. nausea, diarrhoea) and skin rashes have been reported. If skin rash occurs, treatment should be discontinued.
Animal studies with Flucloxacillin have shown no teratogenic effects. The use of Flucloxacillin in pregnancy should be reserved for cases considered essential by the clinician. During lactation, trace quantities of penicillins can be detected in breast milk.
Store in a cool & dry place, protected from light. Flustar® Dry Powder for Suspension should be freshly
prepared. Prepared suspension is to be consumed within 7 days of preparation if kept in room temperature or within 14 days if kept in a refrigerator.
Penicillinase-resistant penicillins
Keep in a dry put absent from light and warm. Keep out of the reach of children.
Renata Limited
by The ACME Laboratories Ltd.
৳10.58