Fluxicap 500

Generic

Flucloxacillin Sodium

Indications

Flucloxacillin is used to treat infections produced by Gram-positive bacteria, particularly infections caused by staphylococci that produce penicillinase. These are some of the signs:

• Infections of the skin and soft tissues: boils, abscesses, carbuncles, and infected skin diseases (e.g. ulcer, eczema, acne, furunculosis, cellulitis, infected wounds, infected burns, otitis media and externa, impetigo).
• Pneumonia, lung abscess, empyema, sinusitis, pharyngitis, tonsillitis, and quinsy are all respiratory tract illnesses.
• It is also used to treat other infections caused by Flucloxacillin-sensitive organisms, such as osteomyelitis, enteritis, endocarditis, urinary tract infection, meningitis, and septicaemia.

Pharmacology

Flucloxacillin is dynamic against Gram-positive life forms counting penicillinase creating strains. It has small movement against Gram-negative bacilli. Flucloxacillin acts by repressing the arrangement of cell divider of microbes. Flucloxacillin is isoxazolyl penicillin which combined the properties of resistance to hydrolysis by penicillinase, gastric corrosive solidness and movement against gram-positive microscopic organisms. Flucloxacillin could be a bactericidal anti-microbial that's especially valuable against penicillinase-producing staphylococci. Flucloxacillin kills bacterial cellwall, in this way interferometer with peptidoglycan blend. Peptidoglycan could be a heteropolymeric structure that gives the cell divider with its mechanical steadiness. The ultimate organize of peptidoglycan union includes the completion of the cross-linking with the terminal glycine buildup of the pentaglycin bridge connecting to the fourth buildup of the pentapeptide (D-alanine).

Dosage & Administration

Oral administration:

• Adult: 250 mg four times daily. Dosage may be doubled in severe infections. In osteomyelitis and endocarditis, up to 8 gm daily is used in 6-8 hourly divided doses.
• Children (2-10 years): 1/2 of adult dose.
• Children (Under 2 years): 1/4 of adult dose.

Parenteral administration:
Adult or Elderly:

• Intramuscular Injection: 250 mg four times daily.
• Intravenous Injection: 250 mg-1 g four times daily by slow injection over 3 to 4 minutes or by intravenous infusion.
• All systemic doses may be doubled in severe infections: doses up to 8 g daily have been suggested for endocarditis or osteomyelitis.

Children:

• 2-10 years: half of the adult dose.
• Under 2 years: a quarter of the adult dose.

Interaction

Flucloxacillin and other drugs used together can cause a prolonged increase in Flucloxacillin levels in the blood.

Contraindications

In patients with penicillin hypersensitivity, flucloxacillin is contraindicated.

Side Effects

Many people have experienced nausea, vomiting, diarrhea and dyspepsia, as well as other mild gastrointestinal problems, which are all frequent gastrointestinal side effects. Urticaria, purpura and fever, interstitial nephritis, Hepatitis, and cholestatic jaundice have also been recorded in addition to these rashes and other skin conditions.

Pregnancy & Lactation

Flucloxacillin is classified as a pregnancy category B by the US Food and Drug Administration. In pregnant women, there are no sufficient and well-controlled trials. Because animal reproduction studies do not always predict human response, this medication should only be used during pregnancy if absolutely necessary. Human milk has been found to contain flucloxacillin. When Flucloxacillin is given to a nursing woman, vigilance should be observed.

Precautions & Warnings

Flucloxacillin should be used with caution in patients with evidence of hepatic dysfunction. Caution should also be exercised in the treatment of patients with allergic diathesis.

Therapeutic Class

Penicillinase-resistant penicillins

Storage Conditions

Pharmaceutical Name

Ziska Pharmaceuticals Ltd.