Lipidof 200

Generic

Fenofibrate.

 

Indications

LIPIDOF 200 (Fenofibrate) is indicated as adjunctive therapy to diet for the treatment of hypertriglyceridemia (Fredrickson Types IV and V) and also for primary hypercholesterolemia or mixed dyslipidemia (Fredrickson Types IIa, IIb) who are at risk of pancreatitis and who do not respond adequately to dietary effort.

 

Pharmacology

Fenofibrate is a fibric corrosive subordinate. Fenofibrate is quickly hydrolyzed after oral ingestion to its pharmacologically dynamic structure, fenofibric corrosive. Fenofibric corrosive produces decreases in complete cholesterol, LDL cholesterol, Apo-lipoprotein B, Total fatty oils and VLDL. What's more, treatment with Fenofibrate brings about expansions in HDL and apo-proteins apoAI apoAII. Fenofibrate additionally diminishes serum uric corrosive levels in hyperuricemic and typical people by expanding the urinary discharge of uric corrosive. The micronized type of Nofiate (Fenofibrate) has improved assimilation over the non-micronized definition.

 

Dosage & Administration

• For the treatment of adult patients with hypercholesterolemia or mixed hyperlipidemia, the initial dose of Fenofibrate is 200 mg per day.
• For adult patients with hypertriglyceridemia, the initial dose is 67 to 200 mg per day.
• Dose should be individualized according to patient response. Fenofibrate should be given with meal there by, optimizing the bioavailability of the medication. Or, as directed by the registered physician.

 

Interaction

Fenofibrate has been accounted for to potentiate the anticoagulant impacts of warfarin. When regulated with antidiabetic drug it might further develop glucose resistance and have added substance impact. Fenofibrate may likewise build the nephrotoxicity of cyclosporine. Because of a likely expansion in the danger of rhabdomyolysis, alerts ought to be taken against the utilization of Fenofibrate with HMG-CoA reductase inhibitors. Be that as it may, the utilization of low-portion statins with Fenofibrate gives off an impression of being all around endured.

 

Contraindications

Fenofibrate is contraindicated in patients who exhibit hypersensitivity to it. Fenofibrate is also contraindicated in patients with hepatic or severe renal dysfunction, including primary biliary cirrhosis, and patients with unexplained persistent liver function abnormality. It is also contraindicated in patients with preexisting gall bladder disease.

 

Pregnancy & Lactation

Pregnant women should avoid using fenofibrate.

 

Precautions & Warnings

During Fenofibrate therapy monitoring of liver function tests in every 3 months for first year should be performed and therapy should be discontinued if enzyme levels persist above three times the normal limit. Use in pregnancy & lactation Pregnancy: Fenofibrate is not recommended for pregnant women. Lactation: Fenofibrate should not be used in lactating mothers. USE IN CHILDREN Safety and effectiveness in children have not been established. Because intoxication with Thyroid preparations may have serious consequences.

 

Therapeutic Class

Fibrates

 

Storage Conditions

Do not store at temperatures above 30°C. Keep out of the reach of youngsters and away from light.

 

Pharmaceutical Name

ACME Laboratories Ltd.