Tigicon

Generic

Fenofibrate

 

Indications

Fenofibrate is used to treat hyperlipidemias of type lla, llb, III, IV, and V in people who haven't reacted well to diet and other treatments.

 

Pharmacology

Fibric acid derivative fenofibrate. After oral consumption, fenofibrate is rapidly hydrolyzed to its pharmacologically active form, fenofibric acid. Total cholesterol, LDL cholesterol, Apo-lipoprotein B, total triglycerides, and VLDL cholesterol are all reduced by fenofibric acid. Furthermore, Fenofibrate medication causes an increase in HDL and apo-proteins apoAI apoAII. Fenofibrate also lowers serum uric acid levels in hyperuricemic and non-hyperuricemic people by increasing uric acid excretion through the urine. In comparison to the non-micronised formulation, the micronised version of Nofiate (Fenofibrate) exhibits better absorption.

 

Dosage & Administration 

For the treatment of adult patients with hypercholesterolemia or mixed hyperlipidemia, the initial dose of Fenofibrate is 200 mg per day.

For adult patients with hypertriglyceridemia, the initial dose is 67 to 200 mg per day.

Dose should be individualized according to patient response. Fenofibrate should be given with meal there by, optimizing the bioavailability of the medication. Or, as directed by the registered physician.

 

Interaction

Fenofibrate has been reported to potentiate the anticoagulant effects of warfarin. When administered with antidiabetic drug it may improve glucose tolerance and have additive effect. Fenofibrate may also increase the nephrotoxicity of cyclosporine. Due to a potential increase in the risk of rhabdomyolysis, cautions should be taken against the use of Fenofibrate with HMG-CoA reductase inhibitors. However, the use of low-dose statins with Fenofibrate appears to be well tolerated..

 

Contraindications

Hypersensitivity to Fenofibrate, severe renal or hepatic impairment, existing gall bladder disease, breast-feeding moms, and photosensitivity to ketoprofen are all contraindications to using Fenofibrate.

 

Side Effects

Gastro-intestinal (e.g. nausea, anorexia, gastric pain), pruritus, urticaria, impotence, also headache, dizziness, vertigo, fatigue, hair loss; myotoxicity.

 

Pregnancy & Lactation

Fenofibrate is not advised for use by pregnant women..

 

Precautions & Warnings

Patients with renal disease should be given extra attention since progressive increases in serum creatinine concentration or failure to follow dosing requirements might lead to myotoxicity; cease if myotoxicity is suspected or if creatinine kinase concentration rises dramatically. For the first year, liver function tests are advised every three months.

 

Therapeutic Class

Fibrates

 

Storage Conditions

Do not store at temperatures above 30°C. Keep out of children's reach.

 

Pharmaceutical Name

Aristopharma Ltd.