Maxolax 10

Indications of Maxolax 10

Indications for Baclofen in-

• Flexor spasms and concomitant pain, clonus and muscular rigidity
• Skeletal muscle spasm resulting from rheumatic disorders
• Spasticity resulting from multiple sclerosis
• Spinal cord injuries and other spinal cord diseases
• Cerebrovascular accidents or neoplastic or degenerative brain disease

 

Pharmacology of Maxolax 10

Baclofen inhibits monosynaptic and polysynaptic reflexes in the spinal cord by activating GABAB receptors, which block glutamate and aspartate release. It may also cause CNS depression by acting at intraspinal locations. Baclofen has an antinociceptive effect as well.

 

Dosage & Administration

Children <10 years: Treatment is usually started with 2.5 mg (2.5 ml) given 4 times daily then raised according to requirement. Daily maintenance dose-

• 12 month-2 years: 10-20 mg (10-20 ml)
• 2 years-6 years: 20-30 mg (20-30 ml)
• 6 years-10 years: 30-60 mg (30-60 ml)

Adult & children over 10 years: 5 mg 3 times daily, preferably with or after food, gradually increased; max. 100 mg daily.

 

Interactions of Maxolax 10

If Baclofen is used with central nervous system depressants, alcohol, or synthetic opiates, more sedation may ensue. Respiratory depression is a possibility as well.

Because combined treatment with Baclofen and antihypertensives is likely to cause a greater drop in blood pressure, the antihypertensive medication dosage should be increased correspondingly.

Baclofen and tricyclic antidepressants used together may enhance the pharmacological effects of Baclofen, resulting in severe muscular hypotonia.

There have been multiple instances of mental confusion, hallucinations, headaches, nausea, and agitation in Parkinson's disease patients using Baclofen with levodopa and carbidopa.

When MAO inhibitors and Baclofen are taken together, the CNS depressive effects may be amplified. Caution is advised, and one or both drugs' dosages should be changed as needed.

 

Contraindications

Baclofen is contraindicated in patients with hypersensitivity to any component of this product.

 

Side-Effects of Maxolax 10

Transient sleepiness, daytime sedation, dizziness, weakness, and exhaustion are the most prevalent side effects of Baclofen.

• Central Nervous System: Headache (10%), sleeplessness (10%), and, less commonly, euphoria, excitement, depression, confusion, hallucinations, paraesthesia, nightmares, muscle pain, tinnitus, slurred speech, co-ordination problem, tremor, stiffness, dystonia, ataxia, and blurred vision, nystagmus, strabismus, miosis, mydriasis, diplopia, dysarthria, epileptic seizures, respiratory depression.
• Cardiovascular: Hypotension (<10%), rare instances of dyspnoea, palpitation, chest pain, syncope.
• Gastrointestinal: Nausea (approximately 10%), constipation (<10%) and rarely, dry mouth, anorexia, taste disorder, abdominal pain, vomiting, diarrhoea and positive test for occult blood in stool.
• Genitourinary: Urinary frequency (<10%) and rarely, enuresis, urinary retention, dysuria, impotence, inability to ejaculate, nocturia, haematuria.
• Other: Instances of rash, pruritus, ankle oedema, excessive perspiration, weight gain, nasal congestion, visual disturbances, hepatic function disorders and paradoxical increase in spasticity. Muscular hypotonia of a degree sufficient to make walking or movement difficult may occur but is usually relieved by readjusting the dosage. For this purpose, the daytime dosage may be reduced and the evening dosage increased.

 

Pregnancy & Lactation

Pregnancy category B3. Safe use of Baclofen during pregnancy has not been established. Baclofen crosses the placental barrier. Baclofen should only be administered to pregnant women when in the judgement of the physician concludes that the potential benefits outweigh the possible hazards. Baclofen is excreted in breast milk however evidence to date suggests that the quantities are so small that no undesirable effects on the infant would be expected.

 

Precautions & Warnings

• Lower doses (approximately 5 mg per day) should be used for patients with impaired renal function or those undergoing chronic haemodialysis.
• Patients suffering not only from spasticity but also from psychotic disorders, schizophrenia, depressive or manic disorders or confusional states should be treated cautiously and closely monitored as exacerbations of these disorders may occur.
• In patients with epilepsy and muscle spasticity, Baclofen may be used under appropriate supervision and provided that adequate anticonvulsive therapy is continued. Lowering of the convulsion threshold may occur and seizures have been reported after the cessation of Baclofen therapy or with overdose.
• Baclofen should be used with caution in patients with or with a history of peptic ulcers, cerebrovascular diseases, or hepatic, renal or respiratory failure.
• Careful monitoring of respiratory and cardiovascular function is essential especially in patients with cardiopulmonary disease and respiratory muscle weakness.
• During treatment with Baclofen, neurogenic disturbances affecting emptying of the bladder may improve. However in patients with preexisting sphincter hypertonia, acute retention of urine may occur. Baclofen should be used with caution in these circumstances.
• Baclofen has not significantly benefited patients with stroke. These patients have also shown poor tolerance to the medicine.
• Appropriate laboratory tests should be performed periodically in patients with hepatic diseases or diabetes mellitus to ensure that no medicine induced changes in these underlying diseases have occurred.

 

Therapeutic Class

Centrally acting Skeletal Muscle Relaxants

 

Storage Conditions

Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.

 

Pharmaceutical Name of Maxolax 10

Renata Limited

 

Generic of Maxolax 10

Baclofen