Cytomis 200 Tablet
by Incepta Pharmaceuticals Ltd
৳15.00
Miptol 200
The ACME Laboratories Ltd.
1 Pc
৳15.04
1 Strip = 10 Pcs
৳150.40
1 Box = 3 Strips
৳451.20
Dosage: Misoprostol 200mcg
Form: Tablet
Generic name(s): Misoprostol 200mcg
Available (pcs): 0
Prescription required: Yes
MIPTOL 200 MCG | THE ACME LABORATORIES LTD | Order Online - OsudPotro
Generic
Misoprostol
Indications
Misoprostol is used to treat the following conditions:
- Stomach and duodenal ulcer prophylaxis among NSAID users at high risk of gastric ulcer complications, such as the elderly, patients with severe illness, and those with a history of ulcer.
- Healing of NSAID-induced gastric and duodenal damage that has already occurred.
- In the absence of NSAID treatment, gastric and duodenal ulcers heal.
- The process of inducing labor.
- Postpartum hemorrhage prevention and treatment
Pharmacology
Misoprostol is rapidly absorbed and de-esterified to its free acid, which is responsible for its therapeutic action and is detectable in plasma, unlike the parent molecule. When taken with food, maximum plasma concentrations of Misoprostol acid are lowered, and overall availability of Misoprostol acid is reduced when an antacid is taken at the same time. Misoprostol possesses antisecretory (gastric acid secretion inhibition) and mucosal protecting effects in animals.NSAIDs suppress prostaglandin production, and a lack of prostaglandins in the stomach mucosa can reduce bicarbonate and mucus secretion, contributing to the mucosal damage produced by these medications. Misoprostol has been proven in humans to enhance bicarbonate and mucus production, however at dosages of 200 meg and above, it is also antisecretory. As a consequence, it's impossible to say if Misoprostol's capacity to lower the incidence of stomach ulcer is due to its antisecretory action, mucosal protective impact, or both.
Dosage & Administration
Benign gastric and duodenal ulceration and NSAID associated ulceration: 800 meg daily (in 2-4 divided doses) with breakfast or main meals and at bedtime; treatment should be continued for at least 4 weeks and may be continued for up to 8 weeks if required.
Prophylaxis of NSAID-induced gastric and duodenal ulcer: 200 meg 2-4 times daily taken with NSAID. If this dose cannot be tolerated, a dose of 100 meg can be used. Misoprostol should be taken for the duration of NSAID therapy as prescribed by the physician.
Induction of labor: Place 25 meg in the posterior fornix of the vagina. Repeat after every 6 hours if necessary until the maximum dosage of 200 meg total misoprostol is reached. Fetal heart rate and uterus contractions should be monitored. Alternatively, 100 meg taken orally. If cervical ripening or active labor does not occur, repeated dose of 100-200 meg of oral misoprostol is given every 4 hourly until labor is established (as evidenced by a Bishop score of 7 or more). Maximum number of dose is 6. Maternal vital signs, fetal heart rate and contractions should be monitored. Oxytocin can be started 4 hours after last dose of misoprostol. Physician should be notified for signs of fetal distress or tetanic uterine contractions. Oral misoprostol therapy should be monitored by Physician.
Prevention of postpartum hemorrhage: 600 meg orally immediately following delivery.
Treatment of postpartum hemorrhage: 600 meg orally or 1000 meg per rectally.
Prophylaxis of NSAID-induced gastric and duodenal ulcer: 200 meg 2-4 times daily taken with NSAID. If this dose cannot be tolerated, a dose of 100 meg can be used. Misoprostol should be taken for the duration of NSAID therapy as prescribed by the physician.
Induction of labor: Place 25 meg in the posterior fornix of the vagina. Repeat after every 6 hours if necessary until the maximum dosage of 200 meg total misoprostol is reached. Fetal heart rate and uterus contractions should be monitored. Alternatively, 100 meg taken orally. If cervical ripening or active labor does not occur, repeated dose of 100-200 meg of oral misoprostol is given every 4 hourly until labor is established (as evidenced by a Bishop score of 7 or more). Maximum number of dose is 6. Maternal vital signs, fetal heart rate and contractions should be monitored. Oxytocin can be started 4 hours after last dose of misoprostol. Physician should be notified for signs of fetal distress or tetanic uterine contractions. Oral misoprostol therapy should be monitored by Physician.
Prevention of postpartum hemorrhage: 600 meg orally immediately following delivery.
Treatment of postpartum hemorrhage: 600 meg orally or 1000 meg per rectally.
Interaction
There is no evidence that Misoprostol interacts with cardiac, pulmonary, CNS, or NSAID medications in a clinically relevant way. With large dosages of antacid, Misoprostol bioavailability is reduced.
Contraindications
Misoprostol is not recommended for anybody who has had a previous reaction to prostaglandins, and it is also not recommended during pregnancy.
Side Effects
Misoprostol is generally well tolerated. The GI tract is the most common side effect of Misoprostol treatment, with diarrhea, stomach discomfort, dyspepsia, flatulence, nausea, vomiting, rashes, and dizziness being the most common. The risk of diarrhea can be reduced by taking the medication after a meal and before night, and by not taking it with a magnesium-containing or other laxative antacid.
Pregnancy & Lactation
It is not recommended for pregnant women due to the abortifacient nature of the Misoprostol component. It should not be used in women of reproductive age unless the patient requires nonsteroidal anti-inflammatory medication (NSAID) therapy and is at high risk of developing gastric or duodenal ulceration or complications from gastric or duodenal ulcers. It may be prescribed in such cases if the patient:
- Has had a negative serum pregnancy test within the last two weeks before starting treatment
- is capable of following through on effective contraception.
- Has been given both spoken and written warnings about the dangers of Misoprostol, including the chance of contraceptive failure and the risk to other women of childbearing potential if the medicine is taken by accident.
- It won't start until the second or third day of the next normal menstrual cycle.
The active metabolite (Misoprostol acid) can be excreted in milk, although this has not been investigated. It is not advised for use by nursing women due to the risk of significant adverse reactions in nursing babies.
Precautions & Warnings
In the case of NSAID-induced gastric and duodenal ulcer prevention and treatment, misoprostol is contraindicated in pregnant women and should not be administered in women of childbearing potential unless the patient necessitates NSAID therapy. Women of childbearing age should be informed that they must not be pregnant when Misoprostol therapy begins, and that they must utilize an effective contraceptive technique while on the medication.
Therapeutic Class
Drugs acting on the Uterus, Prostaglandin analogues
Storage Conditions
Protect against light and moisture by storing in a cool, dry location. Keep it out of the reach of kids.
Pharmaceutical Name
ACME Laboratories Ltd.
