Anfree

Indications

Anfree tablets are used in the following situations:

• Anxiety \ Depression
• Apathy
• Depression is caused by psychological factors.
• Neuroses of depression.
• Depression that isn't visible.
• Anxiety and apathy accompany psychosomatic affections.
• Depressions associated with menopause.
• In drinkers and drug users, dysphoria and despair are common.

 

Pharmacology

This consists of two well-known and well-proven compounds: flupentixol, a neuroleptic with depressive and anxiolytic characteristics at modest dosages, and melitracen, a bipolar thymoleptic with activating qualities in low doses. When the chemicals are combined, they form an antidepressant, anxiolytic, and activating formulation. Flupentixol and melitracen achieve their maximum blood concentrations in around 4 hours after oral dosing. Flupentixol has a biological half-life of 35 hours while melitracen has a biological half-life of 19 hours.

 

Dosage and Administration

Adults: Usually 2 tablets orally daily in the morning and noon. In severe cases, the morning dose may be increased to 2 tablets.

Elderly patients: 1 tablet in the morning.

Maintenance dose: Usually 1 tablet orally in the morning. In cases of insomnia or severe restlessness, additional treatment with a sedative in the acute phase is recommended.

 

Interaction

Alcohol, barbiturates, and other CNS depressants may be enhanced by this tablet. Hypertensive crises may occur if MAO inhibitors are taken at the same time. The antihypertensive effect of guanethidine and similarly acting substances is reduced by neuroleptics and thymoleptics, while the effects of adrenaline and noradrenaline are enhanced by thymoleptics.

 

Contraindications

• After a myocardial infarction, the immediate recovery period begins.
• Bundle-branch conduction defects.
• Narrow-angle glaucoma that has not been treated.
• Intoxication with alcohol, barbiturates, or opiates.
• Patients who have received an MAO inhibitor during the previous two weeks should not take this medication.
• Because of its stimulating impact, it is not suggested for excitable or overactive patients, since it may exaggerate these traits.

 

Side Effects

In the recommended doses side effects are rare. These could be transient restlessness and insomnia.

 

Pregnancy & Lactation

Anfree tablet should preferably not be given during pregnancy and lactation.

 

Precautions & Warnings

If the patient has previously been given tranquilizers having sedative effects, they should be carefully tapered off.

 

Therapeutic Class

Combined anxiolytics & anti-depressant drugs

 

Storage Conditions

Store Anfree in a dry area at a temperature of not more than 30°C. Protect yourself from the sun. Keep out of children's reach.

 

Pharmaceutical Name

Aristopharma Ltd.

 

Generic

Flupentixol + Melitracen

 

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