Angenta

Indications

Angenta tablet is indicated in-

• Anxiety
• Depression
• Apathy
• Psychogenic depression.
• Depressive neurosses.
• Masked depression.
• Psychosomatic affections accompanied by anxiety and apathy.
• Menopausal depressions.
• Dysphoria and depression in alcoholics and drug addicts.

 

Pharmacology

Angenta consists of two well known and well proven compounds: flupentixol-a neuroleptic with anxiolytic and antidepressant properties of its own when given in small doses, and melitracen-a bipolar thymoleptic with activating properties in low doses. In combination the compounds render a preparation with antidepressant, anxiolytic and activating properties. Maximal serum concentration is reached in about 4 hours after oral administration of flupentixol and in about 4 hours after oral administration of melitracen. The biological half-life of flupentixol is about 35 hours and that of melitracen is about 19 hours. The combination of flupentixol and melitracen does not seem to influence the pharmacokinetic properties of the individual compounds.

 

Dosage & Administration

Adults: Usually 2 tablets orally daily in the morning and noon. In severe cases, the morning dose may be increased to 2 tablets.

Elderly patients: 1 tablet in the morning.

Maintenance dose: Usually 1 tablet orally in the morning. In cases of insomnia or severe restlessness, additional treatment with a sedative in the acute phase is recommended.

 

Interaction

This tablet may enhance the response to alcohol, barbiturates and other CNS depressants. Simultaneous administration of MAO-inhibitors may cause hypertensive crises. Neuroleptics and thymoleptics reduce the antihypertensive effect of guanethidine and similar acting compounds and thymoleptics enhance the effects of adrenaline and noradrenaline.

 

Contraindications

• The immediate recovery phase after myocardial infarction.
• Defects in bundle-branch conduction.
• Untreated narrow-angle glaucoma.
• Acute alcohol, barbiturate and opiate intoxications.
• This tablet should not be given to patients who have received an MAO-inhibitor within two weeks.
• Not recommended for excitable or overactive patients since its activating effect may lead to exaggeration of these characteristics.

 

Side Effects

In the recommended doses side effects are rare. These could be transient restlessness and insomnia.

 

Pregnancy & Lactation

This tablet should preferably not be given during pregnancy and lactation.

 

Precautions & Warnings

If previously the patient has been treated with tranquillizers with sedative effect these should be withdrawn gradually.

 

Therapeutic Class

Combined anxiolytics & anti-depressant drugs

 

Storage Conditions

Store at a temperature not exceeding 30°C in a dry place. Protect from light. Keep out of reach of children.

 

Pharmaceutical Name

Healthcare Pharmaceuticals Ltd

 

Generic

Flupentixol + Melitracen

 

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