Avenac 100

Indications of Avenac 100

For the relief of pain and inflammation in osteoarthritis, rheumatoid arthritis and ankylosing spondylitis.

 

Pharmaceutical Name of Avenac 100

Radiant Pharmaceuticals Ltd

 

Pharmacology

Avenac 100 could be a non-steroidal drug with anti-inflammatory and pain relieving properties. It could be a strong inhibitor of the protein cyclooxygenase, which is included within the generation of prostaglandin. After verbal organization, it is quickly and totally ingested an unaltered sedate.

 

Dosage and Administration of Avenac 100

Adults : The recommended dose is 100 mg, twice daily.

Children : There are no clinical data on the use of Aceclofenac in children.

Elderly : The pharmacokinetics of Aceclofenac is not altered in elderly patients, therefore it is not considered necessary to modify the dose or dose frequency.

 

Interactions of Avenac 100

Lithium and Digoxin : Aceclofenac, like many NSAIDs may increase plasma concentrations of lithium and Digoxin.

Diuretics : Aceclofenac, like other NSAIDs, may interact the activity of diuretics.

Anticoagulants : Like other NSAIDs, Aceclofenac may enhance the activity of anticoagulant. Close monitoring of patients on combined anticoagulants and Aceclofenac therapy should be undertaken.

Methotrexate : Caution should be exercised if NSAIDs and Methotrexate are administered within 24 hours of each other, since NSAIDs may increase Methotrexate plasma levels, resulting in increased toxicity.

 

Contraindications

Avenac 100 should not be administered to patients with active or suspected peptic ulcer or gastro-intestinal bleeding. It should not be given to patients with moderate to severe renal impairment. Close medical surveillance is also imperative in patients suffering from severe impairment of hepatic function. It should not be prescribed during pregnancy, unless there are compelling reasons for doing so. The lowest effective dosage should be used. Aceclofenac should not be administered to patients previously sensitive to Aceclofenac or in whom aspirin or NSAIDs precipitate attacks of asthma, acute rhinitis or urticaria or who are hypertensive to these drugs.

 

Side-effects of Avenac 100

The majority of side-effects observed have been reversible and of a minor nature and include gastro-intestinal disorders (dyspepsia, abdominal pain, nausea and diarrhea) and occasional occurrence of dizziness. Dermatological complaints including pruritus and rash and abnormal hepatic enzyme levels and raised serum creatinine have occasionally been reported.

 

Pregnancy and lactation

There is no information on the use of Aceclofenac during pregnancy. The regular use of NSAIDs during the last trimester of pregnancy may increase uterine tone and contraction. There is no information on the secretion of Aceclofenac to breast milk. The use of Aceclofenac should therefore be avoided in pregnancy and lactation unless the potential benefits to the mother outweigh the possible risks to the fetus.

 

Precautions & Warnings

Caution ought to be worked out to patients with dynamic or suspected peptic ulcer or gastro-intestinal dying direct to extreme hepatic disability and cardiac or renal impedance. Caution ought to moreover be worked out in patients enduring from discombobulation or urticaria.

 

Therapeutic Class

Drugs for Osteoarthritis, Drugs utilized for Rheumatoid Joint pain, Non-steroidal Anti-inflammatory Drugs (NSAIDs)

 

Storage Conditions

Store below 30°C in a dry place protected from sunlight.
Keep out of reach of children.

 

Generic Name of Avenac 100

Aceclofenac

 

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