Brezofil 200

Indications of Brezofil 200

Asthma, COPD, and bronchospasm are all treated with doxophylline.

 

Pharmaceutical Name of Brezofil 200

Incepta Pharmaceuticals Ltd.

 

Pharmacology

Doxophylline could be a novel bronchodilator. It fundamentally varies from Theophylline due to the nearness of a dioxolane gather in position 7. Doxophylline specifically hinders phosphodiesterase 4 in this manner unwinds bronchial smooth muscle. In any case, in an unexpected way from Theophylline, Doxophylline shows up to have diminished affinities toward adenosine A1 and A2 receptors, which may account for the superior security profile of the sedate. Doxophylline is detailed to repress platelet enacting figure (PAF) and the era of leukotriene generation.

 

Dosage & Administration

Elderly: 200 mg tablet two or three times daily.

Adults: 400 mg tablet two or three times daily or as prescribed by the physician.

Children:

• >12 years of age: 10 ml syrup or 200 mg tablet two or three times daily.
• 6-12 years of age: 6-9 mg/kg body weight two times daily, i.e., if bodyweight is 10 kg, 3 ml (60 mg) two times daily or as prescribed by the physician.

If a required daily dose of Doxophylline is 400 mg then Doxophylline SR tablet is to be taken once daily or as prescribed by the physician.

 

Interaction of Brezofil 200

Doxophylline ought to not be managed alongside other xanthine subsidiaries. Harmful synergism with ephedrine has been recorded for xanthines. Like other xanthines, concomitant treatment with troleandomycin, lincomycin, clindamycin, allopurinol, cimetidine, ranitidine, propranolol, and anti-flu immunization may diminish the hepatic clearance of xanthines causing an increment in blood levels. No proof of a relationship between Doxophylline serum concentrations and harmful occasions has been detailed.

 

Contraindications

In acute myocardial infarction, doxophylline is contraindicated. Individuals with hypotension, nursing women, and patients who have exhibited allergy to its components are also advised against using it.

 

Side Effect of Brezofil 200

Doxophylline seldom produces major adverse effects, however, it can have the same consequences as taking too much coffee. Nausea, vomiting, headaches, upset stomach, and heartburn are some of the symptoms.

 

Pregnancy & Lactation

Creature generation considers demonstrating that Doxophylline does not cause fetal hurt when managed by pregnant creatures or cannot influence generation capacity. In any case, since there's the restricted encounter in humans amid pregnancy, xanthines ought to be given to pregnant ladies as it were on the off chance that clearly required. Doxophylline is contraindicated in nursing moms.

 

Precautions & Warnings

The half-life of xanthine subsidiaries is affected by a number of known factors. It may be delayed in patients with liver malady, in patients with congestive heart disappointment, and in those patients taking certain other drugs like erythromycin, troleandomycin, lincomycin, allopurinol, cimetidine, propranolol, and anti-flu immunization. In these cases, a lower measurement of Doxophylline may be required. Phenytoin, other anticonvulsants, and smoking may cause an increment in clearance with a shorter cruel half-life. In these cases, higher dosages of Doxophylline may be required.

 

Therapeutic Class

Methylxanthine derivatives, bronchodilator

 

Storage Conditions

Keep in a dry place away from light and heat. Keep out of the reach of children.

 

Generic of Brezofil 200

Doxophylline