Doxiva 200

Indications

Doxiva 200 is used to treat asthma, COPD, and bronchospasm.

 

Pharmacology

Doxophylline is a novel bronchodilator. It structurally differs from Theophylline due to the presence of a dioxolane group in position 7. Doxophylline selectively inhibits phosphodiesterase 4 thereby relaxing bronchial smooth muscle. However, differently from Theophylline, Doxophylline appears to have decreased affinities toward adenosine A1 and A2 receptors, which may account for the better safety profile of the drug. Doxophylline is reported to inhibit platelet-activating factor (PAF) and the generation of leukotriene production.

 

Dosage & Administration

Elderly: 200 mg tablet two or three times daily.

Adults: 400 mg tablet two or three times daily or as prescribed by the physician.

Children:

• >12 years of age: 10 ml syrup or 200 mg tablet two or three times daily.
• 6-12 years of age: 6-9 mg/kg body weight two times daily, i.e. if bodyweight is 10 kg, 3 ml (60 mg) two times daily or as prescribed by the physician.

If a required daily dose of Doxophylline is 400 mg then Doxophylline SR tablet to be taken once daily or as prescribed by the physician

 

Interaction

Doxiva 200 should not be administered together with other xanthine derivatives. Toxic synergism with ephedrine has been documented for xanthines. Like other xanthines, concomitant therapy with troleandomycin, lincomycin, clindamycin, allopurinol, cimetidine, ranitidine, propranolol, and the anti-flu vaccine may decrease the hepatic clearance of xanthines causing an increase in blood levels. No evidence of a relationship between Doxophylline serum concentrations and toxic events has been reported.

 

Contraindications

Doxiva 200 is contraindicated in acute myocardial infarction. It is also contraindicated in patients with hypotension, in lactating women & patients who have shown hypersensitivity to its components.

 

Side Effects

Doxiva 200 rarely causes serious side effects, however possible side effects are similar for taking excess amounts of caffeine. These include nausea, vomiting, headache, upset stomach, and heartburn.

 

Pregnancy & Lactation

Animal reproduction studies indicate that Doxiva 200 does not cause fetal harm when administered to pregnant animals or can not affect reproduction capacity. However, since there is limited experience in humans during pregnancy, xanthines should be given to pregnant women only if clearly needed. Doxiva 200 is contraindicated in nursing mothers.

 

Precautions & Warnings

The half-life of xanthine derivatives is influenced by a number of known variables. It may be prolonged in patients with liver disease, in patients with congestive heart failure, and in those patients taking certain other drugs like erythromycin, troleandomycin, lincomycin, allopurinol, cimetidine, propranolol, and anti-flu vaccine. In these cases, a lower dose of Doxophylline may be needed. Phenytoin, other anticonvulsants, and smoking may cause an increase in clearance with a shorter mean half-life. In these cases, higher doses of Doxophylline may be needed.

 

Therapeutic Class

Bronchodilator, Methylxanthine derivatives

 

Storage Conditions

Keep in a dry place away from light and heat. Keep out of the reach of children. Doxophylline should be used only on the prescription of a specialist physician.

 

Pharmaceutical Name

NIPRO JMI Pharma Ltd.

 

Generic

Doxophylline

 

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• Docopa 200
• Brezofil 200