Lansodin 30

Generic

 

Indications

• Short term treatment of active duodenal ulcer
• Maintenance of healed duodenal ulcers
• Short term treatment of active benign gastric ulcers
• Short term treatment of active erosive esophagitis
• Maintenance of healing of erosive esophagitis
• Pathological hypersecretory conditions including Zollinger- Ellison Syndrome
• H. pylori eradication to reduce the risk of duodenal ulcer recurrence

 

Pharmacology

Lansoprazole is a substituted benzimidazole, and is also known as PPI due to its property to block the final step of acid secretion by inhibiting H⁺/K⁺ ATPase enzyme system in gastric parietal cell. Both basal and stimulated acid are inhibited.

 

Administration & Dosage

Benign gastric ulcer: 30 mg daily in the morning for 8 weeks.

Duodenal ulcer: 30 mg daily in the morning for 4 weeks; maintenance 15 mg.

NSAID-associated duodenal or gastric ulcer: 15-30 mg daily for 4 weeks, followed by a further 4 weeks if not fully healed.

Zollinger-Ellison syndrome (and other hypersecretory conditions): Initially 60 mg once daily adjusted according to response; daily doses of 120 mg or more is given in two divided doses.

Gastroesophageal reflux disease: 30 mg daily in the morning for 4 weeks, followed by a further 4 weeks if not fully healed; maintenance 15-30 mg daily.

Acid-related dyspepsia: 15-30 mg daily in the morning for 2-4 weeks.

 

Interaction

Lansoprazole shows up to be a particular inhibitor of the cytochrome P-450 monooxygenase framework; there may be an impact on hepatic clearance, but there have been no reports to date of clinically pertinent intelligent. There's a few instability over the impact of Lansoprazole on the verbal combined prophylactic pill. Assist appraisal is right now underway. Physiological changes comparative to those found with Omeprazole are likely to require put since of the diminishment in gastric corrosive, which is likely to impact the bacterial colonization of the stomach and duodenum additionally vitamin B12 retention.

 

Contraindications

Lansoprazole is contraindicated in patients with known hypersensitivity to any component of the formulation.

 

Side Effects

Extreme or irreversible antagonistic impacts: The conceivable acceptance of carcinoid tumors by significant corrosive concealment, and a rise in serum gastrin may happen. There's a rise in serum gastrin levels within the to begin with 3 months of treatment, which are at that point kept up in spite of the fact that at a lower level than those found in malignant weakness. Long term treatment with a proton pump inhibitor in patients with Helicobacter pylori contamination may quicken the improvement of atrophic gastritis. Symptomatic unfavorable impact: Measurements subordinate loose bowels happens with an frequency of approximately 4% at 30 mg per day, rising to 8% at 60 mg per day. Cerebral pain happens in 2-3% of treated patients

 

Pregnancy & Lactation

Lansoprazole should be avoided in pregnancy unless there are compelling reasons.

 

Precautions & Warnings

Gastric malignancy should be ruled out. Hepatic impairment. Pregnancy and lactation.

 

Therapeutic Class

Proton Pump Inhibitor

 

Storage Conditions

Store at 25° C.

 

Pharmaceutical Name