Lanz 30

Generic

Lansoprazole

 

Indications

• Treatment of an active duodenal ulcer on a short-term basis
• Maintenance of duodenal ulcers that have healed
• Treatment of active benign gastric ulcers in the short term
• Treatment of active erosive esophagitis in the short term
• Maintenance of erosive esophagitis healing
• pylori eradication can minimize the risk of duodenal ulcer recurrence in pathological hypersecretory diseases such as Zollinger- Ellison Syndrome

 

Pharmacology

Lansoprazole is a substituted benzimidazole that is also known as a proton pump inhibitor (PPI) because it inhibits the H+/K+ ATPase enzyme system in the gastric parietal cell, blocking the final stage of acid secretion. Acid is blocked at both the baseline and stimulated levels.

 

Dosage & Administration

Use in adult:

• Butamirate Citrate 50 mg tablet: 2-3 tablets daily.
• Butamirate Citrate syrup: 15 ml 4 times daily.

Use in children & adolescents:
Butamirate Citrate 50 mg tablet:

• Adolescent over 12 years old: 1-2 tablets daily.

Butamirate Citrate syrup:

• Children (3-6 yrs): 5 ml 3 times daily.
• Children (6-12 yrs): 10 ml 3 times daily.
• Adolescent: 15 ml 3 times daily.

Butamirate Citrate pediatric drops:

• Children ( 2 months- 1 yrs): 0.50 ml 4 times daily.
• Children (1-3 yrs): 0.75 ml 4 times daily.

 

Interaction

Lansoprazole appears to be a selective inhibitor of the cytochrome P-450 monooxygenase system; it may affect hepatic clearance, although no clinically significant interactions have been reported to yet. The impact of Lansoprazole on the oral combination contraceptive pill is still unknown. A more thorough investigation is now ongoing. The decrease in gastric acid is expected to impact bacterial colonization of the stomach and duodenum, as well as vitamin B12 absorption, resulting in physiological effects similar to those seen with Omeprazole.

 

Contraindications

Patients with known hypersensitivity to any component of the formulation should avoid using lansoprazole.

 

Side Effects

Severe or permanent side effects include the possibility of carcinoid tumors being induced by severe acid suppression, as well as an increase in serum gastrin. Serum gastrin levels rise over the first three months of therapy and subsequently remain stable, but at a lower level than in pernicious anemia. In individuals with Helicobacter pylori infection, long-term therapy with a proton pump inhibitor may hasten the onset of atrophic gastritis.

A symptomatic adverse effect is one that occurs as a result of the medication. At 30 mg per day, the incidence of dose-dependent diarrhoea is around 4%, increasing to 8% at 60 mg per day. Headache affects 2% to 3% of individuals who are being treated.

 

Pregnancy & Lactation

Unless there are strong reasons, lansoprazole should be avoided during pregnancy.

 

Precautions & Warnings

Malignancy of the stomach should be checked out. Hepatic dysfunction. Lactation and pregnancy.

 

Therapeutic Class

Proton Pump Inhibitor

 

Storage Conditions

Store at 25° C.

 

Pharmaceutical Name

ACI Limited