Lansopril 30

Generic

Lansoprazole

 

Indications

• Lansoprazole is used to treat active duodenal ulcers in the short term.
• Maintenance of duodenal ulcers that have healed
• Treatment of active benign gastric ulcers in the short term
• Treatment of active erosive esophagitis in the short term
• Maintenance of erosive esophagitis healing
• H. pylori eradication could lower the risk of duodenal ulcer recurrence in pathological hypersecretory diseases such as Zollinger- Ellison Syndrome

 

Pharmacology

Lansoprazole is a substituted benzimidazole that is also known as a proton pump inhibitor (PPI) because it inhibits the H+/K+ ATPase enzyme system in the gastric parietal cell, blocking the final step of acid secretion. Acid is blocked at both the basal and stimulated levels.

 

Dosage & Administration

Benign gastric ulcer: 30 mg daily in the morning for 8 weeks.

Duodenal ulcer: 30 mg daily in the morning for 4 weeks; maintenance 15 mg.

NSAID-associated duodenal or gastric ulcer: 15-30 mg daily for 4 weeks, followed by a further 4 weeks if not fully healed.

Zollinger-Ellison syndrome (and other hypersecretory conditions): Initially 60 mg once daily adjusted according to response; daily doses of 120 mg or more is given in two divided doses.

Gastroesophageal reflux disease: 30 mg daily in the morning for 4 weeks, followed by a further 4 weeks if not fully healed; maintenance 15-30 mg daily.

Acid-related dyspepsia: 15-30 mg daily in the morning for 2-4 weeks.

 

Interaction

Lansoprazole appears to be a selective inhibitor of the cytochrome P-450 monooxygenase system; it may affect hepatic clearance, although no clinically meaningful interactions have been reported to far. The effect of Lansoprazole on the oral combination contraceptive pill is still unknown. A more thorough investigation is presently ongoing. The drop in gastric acid is anticipated to alter bacterial colonization of the stomach and duodenum, as well as vitamin B12 absorption, resulting in physiological effects similar to those seen with Omeprazole.

 

Contraindications

Patients with known hypersensitivity to any component of the formulation should avoid using lansoprazole.

 

Side Effects

Severe or irreversible side effects include the possibility of carcinoid tumors being induced by severe acid suppression, as well as a rise in serum gastrin. Serum gastrin levels rise over the first three months of treatment and subsequently remain stable, though at a lower level than in pernicious anemia. In patients with Helicobacter pylori infection, long-term treatment with a proton pump inhibitor may hasten the onset of atrophic gastritis.

Symptomatic side effect: At 30 mg per day, the incidence of dose-dependent diarrhoea is around 4%, rising to 8% at 60 mg per day. Headache affects 2% to 3% of people who are being treated.

 

Pregnancy & Lactation

Unless there are strong reasons, lansoprazole should be avoided during pregnancy.

 

Precautions & Warnings

Gastric malignancy should be ruled out. Hepatic impairment. Pregnancy and lactation.

 

Therapeutic Class

Proton Pump Inhibitor

 

Storage Conditions

Store at 25° C.

 

Pharmaceutical Name

Amico Laboratories Ltd.