Cartilage MAX

Generic

Glucosamine Sulfate + Diacerein

Indications

This pill is used to treat osteoarthritis.

Rheumatoid arthritis is a type of arthritis that affects the joints.

Injuries to the bones and joints

Pharmacology

Glucosamine: Glucosamine (2-amino-2-deoxy-alpha-D-glucose) could be a common amino sugar, delivered by the body and found in certain nourishments. It is the foremost principal building piece required for biosynthesis of glycosaminoglycans (Chokes) like Hyaluronic Corrosive, Keratan Sulfate and Chondroitin Sulfate. Chokes ties with protein and shape proteoglycans, the fundamental building piece of articular cartilage. When cartilage in a joint break down, Osteoarthritis creates. It moreover makes a difference to make tendons, ligament, nails and various other connective tissues. When we take falsely synthesized Glucosamine Sulfate supplement, it increments Glucosamine level within the body, in this way encourages generation and repair of cartilage. Glucosamine too enacts chondrocytes within the cartilage which offer assistance deliver Chokes and proteoglycans.

In humans, approximately 90% of glucosamine sulfate delivered as an oral dose is absorbed through the digestive tract. The liver is the primary metabolizer, and it is eliminated primarily through urine.

Diacerein is a drug that is used to treat osteoarthritis. It also possesses anti-inflammatory, anti-pyretic, and analgesic properties. It reduces the production of InterLeukin-1 (IL-1), the major cytokine involved in cartilage breakdown, in vitro. It has been proven to have a disease-modifying impact in laboratory models of osteoarthritis and in human subjects with finger joint and knee osteoarthritis due to its particular mode of action.

Diacerein has a 56 percent oral bioavailability. Concurrent food consumption prolongs the duration to peak concentration while increasing absorption by 25%. As a result, diacerein should be taken with food. Binds mostly to protein albumin. Following oral administration, dicerein is metabolized substantially (100%) in the liver. The amount of diacerein excreted in the urine in the form of its metabolites has varied between 35 and 60%.

Dosage & Administration

Use in adults: One tablet twice daily with food.

Use in children and adolescents: The safety and effectiveness of children and adolescents under the age of 18 years have not been established.

Interaction

Antacids containing aluminum and/or magnesium hydroxide can help to reduce Diacerein absorption. Antibiotics or laxatives can increase the risk of diarrhea.

Contraindications

Those who have a hypersensitivity to glucosamine or dicerein should avoid it.

Side Effects

There have been no major side effects reported. Nausea, vomiting, diarrhea, epigastria discomfort, headache, skin rashes, and a bright yellow urine hue are all possible side effects.

Pregnancy & Lactation

This tablet is not recommended for use during pregnancy or nursing.

Precautions & Warnings

In the case of individuals who are allergic to Glucosamine or Diacerein, caution should be exercised when delivering this tablet.

Therapeutic Class

Cartilage Formation Stimulation.

Storage Conditions

Protect from light and moisture by storing in a cool, dry place below 30°C. Keep out of children's reach.

Pharmaceutical Name

Renata Limited