Cosarin

Generic

Glucosamine Sulfate + Diacerein.

Indications

Osteoarthritis, rheumatoid arthritis, and bone and joint injuries are among the conditions for which this medication is prescribed.

Pharmacology

Glucosamine: Glucosamine (2-amino-2-deoxy-alpha-D-glucose) could be a characteristic amino sugar, delivered by the body and found in certain nourishments. It is the foremost principle building square required for the biosynthesis of glycosaminoglycans (Chokes) like Hyaluronic Corrosive, Keratan Sulfate, and Chondroitin Sulfate. Chokes ties with protein and shape proteoglycans, the basic building square of articular cartilage. When cartilage in a joint falls apart, Osteoarthritis creates. It moreover makes a difference to create tendons, ligaments, nails, and various other connective tissues. When we take a falsely synthesized Glucosamine Sulfate supplement, it increments Glucosamine level within the body, in this way encourages generation and repair of cartilage. Glucosamine too enacts chondrocytes within the cartilage which offer assistance to create Chokes and proteoglycans.

In humans, approximately 90% of glucosamine sulfate delivered as an oral dose is absorbed through the digestive tract. The liver is the primary metabolizer, and it is eliminated primarily through urine.

Diacerein: This can be utilized for the treatment of Osteoarthritis. It has too pain-relieving, antipyretic, and anti-inflammatory action. It discharges in vitro and directly restrains the InterLeukin-1(IL-1) union, which is the most cytokine included in cartilage devastation. Due to a particular mode of activity, it has been appeared to have a disease-modifying impact in exploratory models of osteoarthritis and in human subjects with finger joint and knee osteoarthritis. The oral bioavailability of Diacerein is 56%. Concurrent admissions of nourishment delay the time to crest concentration but are related to a 25% increment in assimilation. Subsequently, diacerein is best given with nourishment. Basically, ties with protein egg whites. Diacerein is metabolized extensively (100%) in liver taking after verbal dosing. Urinary excretion of diacerein within the frame of its metabolites has extended between 35% and 60%.

Dosage & Administration

Use in adults: One tablet twice daily with food.

Use in children and adolescents: The safety and effectiveness of children and adolescents under the age of 18 years have not been established.

Interaction

Antacids containing aluminum and/or magnesium hydroxide can help to reduce Diacerein absorption. Antibiotics or laxatives can increase the risk of diarrhea.

Contraindications

Contraindicated for those who appear extreme touchiness to Glucosamine or Diacerein.

Side Effect

No genuine antagonistic impact has been detailed. Queasiness, spewing, loose bowels, epigastria torment, cerebral pain, skin rashes & strongly yellow coloring of pee maybe happened.

Pregnancy & Lactation

This tablet is not recommended for use during pregnancy or nursing.

Precautions & Warnings

Caution should be practiced when administering this tablet in the case of patients who are allergic to Glucosamine or Diacerein.

Therapeutic Class

Cartilage Formation Stimulation.

Storage Conditions

Keep the temperature below 30°C and away from light and moisture. Keep out of children's reach.

Pharmaceutical Name

Opsonin Pharma Ltd.