Omidon 10 Tablet
by Incepta Pharmaceuticals Ltd
৳3.50
Popular Pharmaceuticals Ltd.
Domilux 10 mg Tablet is used in the treatment of Indigestion, Nausea, Vomiting. View Domilux Tablet usage, price, side effect & alternative Medicines. Order online at the best price from osudpotro.
Complicated dyspeptic symptoms, often associated with delayed gastric emptying, gastroesophageal reflux and esophagitis:
Domperidone is a dopamine antagonist that primarily blocks dopamine receptors located in the chemoreceptor trigger zone (CTZ) and the stomach. Its gastric stimulating effect is based on the blocking effect of dopamine receptors which affect gastrointestinal motility. Due to its poor ability to penetrate the blood-brain barrier, domperidone has virtually no effect on dopaminergic receptors in the brain, thus ruling out neuroleptic and psychotropic side effects. Domperidone restores normal peristalsis and tone of the upper gastrointestinal tract, facilitates gastric emptying, improves intestinal and duodenal motility, and regulates pyloric contraction. Domperidone also increases esophageal motility and lowers the pressure of the esophageal sphincter, thus preventing acid reflux.
Domperidone should be taken 15-30 minutes before meals and, if necessary, before retiring.
The usual recommended oral dose of Domperidone is as follows:
Adults: 10-20 mg (1-2 tablet or 10-20 ml suspension), every 6-8 hours daily. The maximum dose of Domperidone is 80 mg daily.
Children: 2-4 ml suspension/10 kg body weight or 0.4-0.8 ml paediatric drops/10 kg body weight, every 6-8 hours daily.
In dyspeptic symptom:
Adults: 10-20 mg (1-2 tablet or 10-20 ml suspension), every 6-8 hours daily.
Children: 0.2-0.4 mg/kg (2-4 ml suspension/10 kg or 0.4-0.8 ml paediatric drops/10 kg) body weight, every 6-8 hours daily.
In acute and sub-acute conditions (mainly in acute nausea and vomiting):
Adults: 20 mg (2 tablets or 20 ml suspension), every 6-8 hours daily
Children: 0.2-0.4 mg/kg (2-4 ml suspension/10 kg or 0.4-0.8 ml paediatric drops/10 kg) body weight, every 6-8 hours daily. (In acute nausea and vomiting maximum period of treatment is 12 weeks).
By rectum in suppositories:
Adults (including elderly): 30-60 mg every 4-8 hours.
Children: The maximum daily dose rectally in children's is 30 mg for those weighting 10 to 25 kg. The dose may be divided throughout day if necessary.
The maximum period of treatment is 12 weeks.
Domperidone may reduce the risk of the blood-flow-reducing effects of bromocriptine. The effect of domperidone on Gl function may be interfered with by analgesics and opioid analgesics. Caution should be exercised when domperidone is used in combination with MAO (monoamine oxidase) inhibitors.
Domperidone is contraindicated in patients and newborns who are known to be allergic to this drug. Domperidone should not be used when gastrointestinal irritation is dangerous, that is, gastrointestinal bleeding, mechanical obstruction or perforation. Patients with prolactin-releasing pituitary tumors (prolactinomas) are also contraindicated.
Domperidone may cause hyperprolactinemia (1.3%). This can lead to bleeding, breast enlargement, pain, and decreased sex drive. Dry mouth (1%), thirst, headache (1.2%), anxiety, drowsiness (0.4%), diarrhea (0.2%), rash and itching (0.1%) may occur during treatment with domperidone. Extrapyramidal reactions were observed in 0.05% of patients in clinical studies.
The safety of domperidone has not been established and is therefore not recommended during pregnancy. Animal studies have not demonstrated teratogenic effects in the fetus. Domperidone can precipitate galactorrhea and improve lactation after delivery. It is secreted in breast milk but in very small amounts not enough to be considered harmful.
Domperidone should be used with extreme caution in children due to the possible increased risk of extrapyramidal reactions in young children due to incomplete development of the blood brain barrier. Since domperidone is extensively metabolized in the liver, it should be used with caution in patients with hepatic impairment.
Motility Stimulants, Motility stimulants/Dopamine antagonist, Prokinetic drugs
Store below 30°C, Protected from light & moisture. Keep out of children's reach.
by Opsonin Pharma Limited
৳3.53