Omidon 10 Tablet
by Incepta Pharmaceuticals Ltd
৳3.50
Radiant Pharmaceuticals Limited
Efodio 10 mg Tablet is used in the treatment of Indigestion, Nausea, Vomiting. View Efodio Tablet usage, price, side effect & alternative Medicines. Order online at the best price from osudpotro.
Domperidone is a selective peripheral dopamine D2 receptor antagonist that principally blocks the dopamine receptors located in the Chemoreceptor Trigger Zone (CTZ) and stomach. Its gastroprokinetic action is based on its blocking effect of dopamine receptors that have an influence on the motility of gastro-intestinal tract. Due to its weak penetration across the blood-brain-barrier, Domperidone has almost no effect on the dopaminergic receptors in the brain, therefore excluding psychotropic and neurologic side effects. Domperidone restores normal motility and tone of the upper gastro-intestinal tract, facilitates gastric emptying, enhances antral and duodenal peristalsis and regulates contraction of the pylorus. Domperidone also increases esophageal peristalsis and lower esophageal sphincter pressure and thus prevents regurgitation of gastric content.
Efodio 10 mg tablet should be taken 15-30 minutes before meals and, if necessary, before retiring.
The usual recommended oral dose of Domperidone is as follows:
In dyspeptic symptom:
In acute and sub-acute conditions (mainly in acute nausea and vomiting):
By rectum in suppositories:
Bromocriptine's hypoprolactemic impact may be reduced by domperidone. Antimuscarinics and opioid analgesics may counteract Domperidone's effect on Gl function. When domperidone is used with MAO (monoamine oxidase) inhibitors, caution should be exercised.
Efodio 10 mg is contraindicated to patients having known hypersensitivity to this drug and in the case of neonates. Domperidone should not be used whenever gastro-intestinal stimulation might be dangerous, like in the case of gastrointestinal hemorrhage, mechanical obstruction, or perforation. It is also contraindicated in patients with prolactin releasing pituitary tumors (prolactinoma).
Efodio 10 mg may produce hyperprolactinemia (1.3% frequency). This may result in galactorrhea, breast enlargement and soreness, and reduced libido. Dry mouth (1.9%), thirst, headache (1.2%), nervousness, drowsiness (0.4%), diarrhea (0.2%), skin rash and itching (0.1%) may occur during treatment with Domperidone. Extra-pyramidal reactions are seen in 0.05% of patients in clinical studies.
Pregnant women: The safety of Domperidone has not been proven and it is therefore not recommended during pregnancy. Animal studies have not demonstrated teratogenic effects on the fetus.
Lactating mother: Domperidone may precipitate galactorrhea and improve post-natal lactation. It is secreted in breast milk but in very small quantities, insufficient to be considered harmful. Drug Interactions: Domperidone may reduce the hypoprolactinemic effect of Bromocriptine. Anti-muscarinics and opioid analgesics may antagonize the action of Domperidone on GI function. Care should be taken when Domperidone is administered in combination with MAO (Monoamine oxidase) inhibitors.
Efodio 10 mg should be used with absolute caution in the case of children because there may be an increased risk of extra-pyramidal reactions in young children because of an incompletely developed blood-brain barrier. Since Domperidone is highly metabolized in the liver, it should be used with caution in patients with hepatic impairment.
Prokinetic medicines, Motility stimulants/Dopamine antagonists, Motility stimulants/Dopamine antagonists
Store in a cool & dry place below 30ºC, protect from light & moisture. Keep out of reach of children.
by Opsonin Pharma Limited
৳3.53