Omidon 10

Indications of Omidon 10

Dyspeptic symptom complex, often associated with delayed gastric emptying, gastroesophageal reflux, and esophagitis:

• Epigastric sense of fullness, feeling of abdominal distension, upper abdominal pain
• Eructation, flatulence, early satiety
• Nausea and vomiting
• Heartburn with or without regurgitations of gastric contents in the mouth
• Non-ulcer dyspepsia

Acute nausea and vomiting of the functional, organic, infectious, dietetic origin or induced by radiotherapy or drug therapy or induced in migraine.

Parkinson's disease: In dopamine-agonist induced nausea and vomiting.

Radiological studies: Speeding barium transit in follow-through radiological studies.

 

Pharmaceutical Name of Omidon 10

Incepta Pharmaceuticals Ltd.

 

Pharmacology

Domperidone could be a dopamine opponent that principally squares the dopamine receptors found within the ChemoreceptorTrigger Zone (CTZ) and stomach. Its gastroprokinetic activity is based on its blocking impact of dopamine receptors that have an impact on the motility of the gastrointestinal tract. Due to its frail entrance over the blood-brain barrier, Omidon 10 mg has nearly no impact on the dopaminergic receptors within the brain, in this manner, barring psychotropic and neurologic side impacts. Domperidone reestablishes typical motility and tone of the upper gastrointestinal tract, encourages gastric purging, upgrades antral and duodenal peristalsis, and controls the compression of the pylorus. Domperidone moreover increments esophageal peristalsis and lower esophageal sphincter weight and hence avoids spewing forth of gastric substance.

 

Dosage & Administration of Omidon 10

Omidon 10 mg tablet should be taken 15-30 minutes before meals and, if necessary, before retiring.

The usual recommended oral dose of Domperidone is as follows:

• Adults: 10-20 mg (1-2 tablet or 10-20 ml suspension), every 6-8 hours daily. The maximum dose of Domperidone is 80 mg daily.
• Children: 2-4 ml suspension/10 kg body weight or 0.4-0.8 ml paediatric drops/10 kg body weight, every 6-8 hours daily.

In dyspeptic symptom:

• Adults: 10-20 mg (1-2 tablet or 10-20 ml suspension), every 6-8 hours daily.
• Children: 0.2-0.4 mg/kg (2-4 ml suspension/10 kg or 0.4-0.8 ml paediatric drops/10 kg) body weight, every 6-8 hours daily.

In acute and sub-acute conditions (mainly in acute nausea and vomiting):

• Adults: 20 mg (2 tablets or 20 ml suspension), every 6-8 hours daily
• Children: 0.2-0.4 mg/kg (2-4 ml suspension/10 kg or 0.4-0.8 ml paediatric drops/10 kg) body weight, every 6-8 hours daily. (In acute nausea and vomiting maximum period of treatment is 12 weeks).

By rectum in suppositories:

• Adults (including elderly): 30-60 mg every 4-8 hours.
• Children: The maximum daily dose rectally in children's is 30 mg for those weighting 10 to 25 kg. The dose may be divided throughout day if necessary.
• The maximum period of treatment is 12 weeks.

 

Interaction of Omidon 10

Bromocriptine's hypoprolactemic impact may be reduced by domperidone. Antimuscarinics and opoid analgesics may counteract Domperidone's effect on Gl function. When domperidone is used with MAO (monoamine oxidase) inhibitors, caution should be exercised.

 

Contraindications

Omidon 10 mg is contraindicated to patients having known extreme touchiness to this sedate and within the case of neonates. Domperidone ought to not be used whenever gastrointestinal incitement may well be unsafe i.e., gastrointestinal hemorrhage, mechanical obstacle or puncturing. Too contraindicated in patients with prolactin discharging pituitary tumor (prolactinoma).

 

Side Effects

Hyperprolactinemia is a side effect of domperidone (1.3 percent ). Galactorrhea, breast growth, discomfort, and a decrease in libido are all possible side effects. During domperidone treatment, dry mouth (1 percent), thirst, headache (1.2 percent), nervousness, drowsiness (0.4 percent), diarrhea (0.2 percent), skin rash, and itching (0.1 percent) are all possible side effects. Clinical investigations show that extrapyramidal responses occur in 0.05 percent of patients.

 

Pregnancy & Lactation

The security of domperidone has not been demonstrated and it is subsequently not prescribed amid pregnancy. Creature considers have not illustrated the teratogenic impact within the baby. Omidon 10 mg may accelerate galactorrhea and progress post-natal lactation. It is emitted in breast drain but in exceptionally little amounts inadequately to be considered hurtful.

 

Precautions & Warnings

Omidon 10 mg ought to be utilized with supreme caution within the case of children since there may be an expanded chance of extrapyramidal responses in youthful children since of a not entirely created blood-brain boundary. Since domperidone is profoundly metabolized in the liver, it ought to be utilized with caution in persistent hepatic disability.

 

Therapeutic Class

Prokinetic medicines, Motility stimulants/Dopamine antagonists, Motility stimulants/Dopamine antagonists

 

Storage Conditions

Do not store at temperatures above 30°C. Keep out of the reach of youngsters and away from light.

 

Generic Name of Omidon 10

Domperidone Maleate.

 

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