Dysnov

Generic

Domperidone Maleate

 

Indications

A complex of dyspeptic symptoms, generally related to delayed gastric emptying, gastroesophageal reflux, and esophagitis:

•  Fullness, upper abdominal distention, upper abdominal pain
•  Belching, flatulence, early satiety
•  Nausea and vomiting
•  Heartburn with or without gastric reflux in the mouth
•  Non-ulcer dyspepsia

Acute, functional, organic, infectious nausea and vomiting, of the dietary origin or induced by radiotherapy or pharmacotherapy or induced by migraine.

Parkinson's disease: nausea and vomiting caused by dopamine receptor agonists.

Radiological Investigation: Accelerate Barium Transport in Follow-up Radiological Investigation.

 

Pharmacology

Domperidone is a dopamine antagonist that primarily blocks dopamine receptors located in the chemoreceptor activation zone (CTZ) and the stomach. Its gastrointestinal motility is based on its blocking effect on dopamine receptors that affect gastrointestinal motility. Due to its weak penetration of the blood-brain barrier, domperidone has almost no effect on dopamine receptors in the brain, thus eliminating side effects on the nervous and mental systems. Domperidone restores normal movement and tension in the upper gastrointestinal tract, promotes gastric emptying, improves gastric antrum and duodenal peristalsis, and regulates pyloric contraction. Domperidone also increases esophageal motility and reduces esophageal sphincter pressure, thus preventing reflux of stomach contents.

 

Dosage & Administration

Dysnov 10 mg tablet should be taken 15-30 minutes before meals and, if necessary, before retiring.

The usual recommended oral dose of Domperidone is as follows:

• Adults: 10-20 mg (1-2 tablets or 10-20 ml suspension), every 6-8 hours daily. The maximum dose of Domperidone is 80 mg daily.
• Children: 2-4 ml suspension/10 kg body weight or 0.4-0.8 ml pediatric drops/10 kg body weight, every 6-8 hours daily.

In dyspeptic symptoms:

• Adults: 10-20 mg (1-2 tablets or 10-20 ml suspension), every 6-8 hours daily.
• Children: 0.2-0.4 mg/kg (2-4 ml suspension/10 kg or 0.4-0.8 ml paediatric drops/10 kg) body weight, every 6-8 hours daily.

In acute and sub-acute conditions (mainly in acute nausea and vomiting):

• Adults: 20 mg (2 tablets or 20 ml suspension), every 6-8 hours daily
• Children: 0.2-0.4 mg/kg (2-4 ml suspension/10 kg or 0.4-0.8 ml paediatric drops/10 kg) body weight, every 6-8 hours daily. (In acute nausea and vomiting maximum period of treatment is 12 weeks).

By rectum in suppositories:

• Adults (including elderly): 30-60 mg every 4-8 hours.
• Children: The maximum daily dose rectally in children's is 30 mg for those weighting 10 to 25 kg. The dose may be divided throughout day if necessary.
• The maximum period of treatment is 12 weeks.

 

Interaction

Bromocriptine's hypoprolactemic impact may be reduced by domperidone. Antimuscarinics and opoid analgesics may counteract Domperidone's effect on Gl function. When domperidone is used with MAO (monoamine oxidase) inhibitors, caution should be exercised.

 

Contraindications

Dysnov 10 mg is not recommended for patients who have a known hypersensitivity to the medicine or for neonates. When gastrointestinal stimulation is potentially harmful, such as gastrointestinal hemorrhage, mechanical obstruction, or perforation, do not use domperidone. Patients with a prolactin-releasing pituitary tumor are also advised against taking it (prolactinoma).

 

Side Effects

Hyperprolactinemia is a side effect of domperidone (1.3 percent ). Galactorrhea, breast growth, discomfort, and a decrease in libido are all possible side effects. During domperidone treatment, dry mouth (1 percent), thirst, headache (1.2 percent), nervousness, drowsiness (0.4 percent), diarrhea (0.2 percent), skin rash, and itching (0.1 percent) are all possible side effects. Clinical investigations show that extrapyramidal responses occur in 0.05 percent of patients.

 

Pregnancy & Lactation

Because the safety of domperidone has not been established, it is not recommended for use during pregnancy. The teratogenic effect in the fetus has not been shown in animal research. Domperidone can help with galactorrhea and postpartum lactation. It's secreted in breast milk, but in such small amounts that it's not considered dangerous.

 

Precautions & Warnings

Dysnov 10 mg should be used with extreme caution in children due to an elevated risk of extrapyramidal effects due to an incompletely established blood-brain barrier in young children. Dysnov 10 mg should be taken with caution in patients with hepatic impairment since it is highly metabolized in the liver.

 

Therapeutic Class

Motility Stimulants, Motility stimulants/Dopamine antagonist, Prokinetic drugs

 

Storage Conditions

Store below 30°C, Protected from light & moisture. Keep out of children's reach.

 

Pharmaceutical Name

UniMed UniHealth

 

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