Omidon 10 Tablet
by Incepta Pharmaceuticals Ltd
৳3.50
Renata Pharma Ltd
Domiren 10 mg Tablet by The Renata Limited is available in our online pharmacy. Place your order in Osudpotro and get online medicine home delivery.
Acute nausea and vomiting of the functional, organic, infectious, dietetic origin or induced by radiotherapy or drug therapy or induced in migraine.
Domperidone is a dopamine antagonist that principally blocks the dopamine receptors located in the ChemoreceptorTrigger Zone (CTZ) and stomach. Its gastroprokinetic action is based on its blocking effect of dopamine receptors that have an influence on the motility of the gastrointestinal tract. Due to its weak penetration across the blood-brain barrier, Domperidone has almost no effect on the dopaminergic receptors in the brain, therefore, excluding psychotropic and neurologic side effects. Domperidone restores normal motility and tone of the upper gastrointestinal tract, facilitates gastric emptying, enhances antral and duodenal peristalsis and regulates contraction of the pylorus. Domperidone also increases esophageal peristalsis and lower esophageal sphincter pressure, and thus prevents regurgitation of gastric content.
Domiren 10 mg tablet should be taken 15-30 minutes before meals and, if necessary, before retiring.
The usual recommended oral dose of Domperidone is as follows:
In dyspeptic symptoms:
In acute and sub-acute conditions (mainly in acute nausea and vomiting):
By rectum in suppositories:
The maximum period of treatment is 12 weeks.
Domiren 10 mg may reduce the risk of hypoprolactemic effect of bromocriptine. The action of Domperidone on Gl function may be antagonized by antimuscarinics and opioid analgesics. Care should be exercised when domperidone is administered in combination with MAO (monoamine oxidase) inhibitors.
Domiren 10 mg is contraindicated to patients having known hypersensitivity to this drug and in the case of neonates. Domperidone should not be used whenever gastrointestinal stimulation might be dangerous i.e., gastrointestinal hemorrhage, mechanical obstruction, or perforation. Also contraindicated in patients with prolactin releasing pituitary tumor (prolactinoma).
Domiren 10 mg may produce hyperprolactinemia (1.3%).This may result in galactorrhea, breast enlargement, and soreness, and reduced libido. Dry mouth (1%), thirst, headache (1.2%), nervousness, drowsiness (0.4%), diarrhea (0.2%), skin rash, and itching (0.1%) may occur during treatment with domperidone. Extra-pyramidal reactions are seen in 0.05% of patients in clinical studies.
The safety of domperidone has not been proven and it is therefore not recommended during pregnancy. Animal studies have not demonstrated the teratogenic effect in the fetus. Domiren 10 mg may precipitate galactorrhea and improve post-natal lactation. It is secreted in breast milk but in very small quantities insufficient to be considered harmful.
Domiren 10 mg should be used with absolute caution in the case of children because there may be an increased risk of extrapyramidal reactions in young children because of an incompletely developed blood-brain barrier. Since domperidone is highly metabolized in the liver, it should be used with caution in patients with hepatic impairment.
Motility Stimulants, Motility stimulants/Dopamine antagonist, Prokinetic drugs
Store below 30°C, Protected from light & moisture. Keep out of children's reach.
by Opsonin Pharma Limited
৳3.53